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Hemiplegia and Headache: a Review of Hemiplegia in Headache Disorders

  • Uncommon and/or Unusual Headaches and Syndromes (J Ailani, Section Editor)
  • Published:
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Abstract

The most common scenario wherein the practicing neurologist is likely to encounter a patient with headache and hemiplegia will vary depending on his/her specific type of practice. A neurologist providing consultative service to an emergency department is far more likely to see patients with “secondary” headache and hemiplegia in the setting of either ischemic or hemorrhagic stroke than hemiplegia as a transient feature of a primary headache disorder. Neurologists subspecializing in headache medicine who practice in a tertiary referral headache clinic are more likely to encounter hemiplegic migraine, but even in that clinical setting hemiplegic migraine is by no means a frequent diagnosis. The acute onset of hemiplegia can be very frightening not only to the patient but also to the medical personnel. Given the abundance of mimicry, practitioners must judiciously ascertain the correct diagnosis as treatment may greatly vary depending on the cause of both headache and hemiplegia. In this review, we will address the most common causes of hemiplegia associated with headache.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Ferro J, Canhao P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke. 2004;35(3):664–70.

    Article  PubMed  Google Scholar 

  2. Rasmussen BK, Olesen J. Symptomatic and nonsymptomatic headaches in a general population. Neurology. 1992;42:1225–31.

    Article  CAS  PubMed  Google Scholar 

  3. Mackey J. Evaluation and management of stroke in young adults. Continuum. 2014;20(2):352–69.

    PubMed  Google Scholar 

  4. Vahedi K, Chabriat H, Levy C, et al. Migraine with aura and brain magnetic resonance imaging abnormalities in patients with CADASIL. Arch Neurol. 2004;61(8):1237–40.

    PubMed  Google Scholar 

  5. Pavlakis SG, Phillips PC, DiMauro S, et al. Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome. Ann Neurol. 1984;16(4):481–8.

    Article  CAS  PubMed  Google Scholar 

  6. Runchey S, McGee S. Does this patient have a hemorrhagic stroke? Clinical findings distinguishing hemorrhagic stroke from ischemic stroke. JAMA. 2010;30:2280–6.

    Article  Google Scholar 

  7. Viana M, Sprenger T, Andelova M, et al. The typical duration of migraine aura: a systematic review. Cephalalgia. 2013;33:483–90.

    Article  PubMed  Google Scholar 

  8. Ward T. Migraine diagnosis and pathophysiology. Contin Lifelong Learn Neurol. 2012;18(2):753–4.

    Article  Google Scholar 

  9. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33:629–808. This is the newest classification of headache disorders and everyone interested in headaches should be familiar with this classification.

  10. Akerman S, Holland PR, Goadsby PJ. Diencephalic and brainstem mechanisms in migraine. Nat Rev Neurosci. 2011;12:570–84.

    Article  CAS  PubMed  Google Scholar 

  11. Zhang X, Levy D, Noseda R, et al. Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci. 2010;30:8807–14.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Eikerman-Haerter K. Spreading depolarizing may link migraine and stroke. Headache. 2014;54:1146–57. Insightful article on the link between migraine and stroke.

    Article  Google Scholar 

  13. Tzouri C, Tehindrazanarivelo A, Iglesias S, et al. Case–control study of migraine and risk of ischemic stroke in young women. BMJ. 1995;310:830–3.

    Article  Google Scholar 

  14. Buring J, Hebert P, Romero J, et al. Migraine and subsequent risk of stroke in the Physician’s Health Study. Arch Neurol. 1995;52:129–34.

    Article  CAS  PubMed  Google Scholar 

  15. Merikangas K, Fenton B, Cheng S, et al. Association between migraine and stroke in a large-scale epidemiological study of the United States. Arch Neurol. 1997;54:362–8.

    Article  CAS  PubMed  Google Scholar 

  16. Kurth T, Slomke M, Kase C, et al. Migraine, headache and the risk of stroke in women: a prospective study. Neurology. 2005;64:1020–6.

    Article  CAS  PubMed  Google Scholar 

  17. Headache Classification Committee of the International Headache Society. ICHD-II abbreviated pocket version. Cephalalgia. 2004;24 Suppl 1:1–160.

    Google Scholar 

  18. Russell MB, Ducros A. Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management. Lancet Neurol. 2011;10:457–70.

    Article  PubMed  Google Scholar 

  19. Heron SE, Dibbens LM. Role of PRRT2 in common paroxysmal neurological disorders: a gene with remarkable pleiotropy. J Med Genet. 2013;50:133–9.

    Article  CAS  PubMed  Google Scholar 

  20. Riant F, Roze E, Barbance C, et al. PRRT2 mutations cause hemiplegic migraine. Neurology. 2012;79:2122–4.

    Article  CAS  PubMed  Google Scholar 

  21. Marini C, Conti V, Mei D, et al. PRRT2 mutations in familial infantile seizures, paroxysmal dyskinesia, and hemiplegic migraine. Neurology. 2012;79:2109–14.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Pelzer N, de Vries B, Kamphorst J, et al. PRRT2 and hemiplegic migraine: a complex association. Neurology. 2014;83:288–90.

    Article  PubMed  Google Scholar 

  23. Fedak EM, Zumberge NA, Heyer GL. The diagnostic role for susceptibility-weighted MRI during sporadic hemiplegic migraine. Cephalalgia. 2013;0(0):1–6.

  24. Hansen JM, Schytz HW, Larsen VA, et al. Hemiplegic migraine aura with cerebral hypoperfusion: imaging in the acute phase. Headache. 2011;51:1289–96.

    Article  PubMed  Google Scholar 

  25. Lizuka T, Takahashi Y, Sato M, et al. Neurovascular changes in prolonged migraine aura in FHM with a novel ATP1A2 gene mutation. J Neurol Neurosurg Psychiatry. 2011. doi:10.1136/jnnp-2011-300843.

    Google Scholar 

  26. Mourand I, Menjot de Champfleur N, Carra-Dalleiere C, et al. Perfusion-weighted imaging in persistent hemiplegic migraine. Neuroradiology. 2012;54:255–60.

    Article  PubMed  Google Scholar 

  27. Sugrue G, Bolster F, Crosbie I, Kavanagh E. Hemiplegic migraine: neuroimaging findings during a hemiplegic migraine attack. Headache. 2014;54:716–8.

    Article  PubMed  Google Scholar 

  28. Schwedt TJ, Zhou J, Dodick DW. Sporadic hemiplegic migraine w permanent neurologic deficits. Headache. 2014;54:163–6.

    Article  PubMed Central  PubMed  Google Scholar 

  29. Shevel E. Arterial surgery for sporadic hemiplegic migraine: preliminary results. Br J Oral Maxillofac Surg. 2014;52:405–8.

    Article  PubMed  Google Scholar 

  30. Tentschert S, Wimmer R, Greisenegger S, Lang W, Lalouschek W. Headache at stroke onset in 2196 patients with ischemic stroke or transient ischemic attack. Stroke. 2005;36:e1–3.

    Article  PubMed  Google Scholar 

  31. Gorelick P, Hier D, Caplan L, et al. Headache in acute cerebrovascular disease. Neurology. 1986;36:1445–50.

    Article  CAS  PubMed  Google Scholar 

  32. Grindal A, Toole J. Headache and transient ischemic attacks. Stroke. 1974;5:603–6.

    Article  CAS  PubMed  Google Scholar 

  33. Jorgenson H, Jespersen H, Nakayama H, et al. Headache and stroke: the Copenhagen stroke study. Neurology. 1994;44:1793–7.

    Article  Google Scholar 

  34. Evans R, Mitsias P. Headache at the onset of acute cerebral ischemia. Headache. 2009;49:902–8.

    Article  PubMed  Google Scholar 

  35. Fisher C. Headache in cerebrovascular disease. In: Vinken P, Bruyn G, editors. Handbook of clinical neurology, vol. 5. Amsterdam: North Holland Publishing; 1968. p. 124.

    Google Scholar 

  36. Medina J, Diamond S, Rubino S. Headaches in patients with transient ischemic attacks. Headache. 1975;15:194.

    Article  CAS  PubMed  Google Scholar 

  37. Edmeads J. The headaches of ischemic cerebrovascular disease. Headache. 1979;19:345–9.

    Article  CAS  PubMed  Google Scholar 

  38. Ferro J, Melo T, Oliveiro A, et al. A multivariate study of headache associated with ischemic stroke. Headache. 1995;35:315–9.

    Article  CAS  PubMed  Google Scholar 

  39. Pickard J, Mackenzie E, Harper A. Serotonin and prostaglandins: intracranial and extracranial effects with reference to migraine. In: Green R, editor. Current concepts in migraine research. New York: Raven; 1978. p. 101.

    Google Scholar 

  40. Murinova N, Krashin D, Lucas S. Vascular risk in migraineurs: interaction of endothelial and cortical excitability factors. Headache. 2012;54:583–90.

    Article  Google Scholar 

  41. Silbert P, Mokri B, Schievink W. Headache and neck pain in spontaneous internal carotid and vertebral artery dissections. Neurology. 1995;45:1517–22.

    Article  CAS  PubMed  Google Scholar 

  42. Mokri B, Sundt T, House O. Spontaneous internal carotid dissection, hemicrania and Horner’s syndrome.

  43. Girot M, Ferro JM, Canhao P, et al. Predictors of outcome in patients with cerebral venous thrombosis and intracerebral hemorrhage. Stroke. 2007;38(2):337–42.

    Article  PubMed  Google Scholar 

  44. Bousser M, Barnett H. Cerebral venous thrombosis. In: Barnett H, Mohr J, Stein B, et al., editors. Stroke: pathology, diagnosis and management. 2nd ed. New York: Churchill and Livingston; 1992. p. 522.

    Google Scholar 

  45. Bousser M, Chiras J, Sauron B, et al. Cerebral venous thrombosis: a review of 38 cases. Stroke. 1985;16:199–213.

    Article  CAS  PubMed  Google Scholar 

  46. Levine S, Twyman R, Gilman S. The role of anticoagulation in cavernous sinus thrombosis. Neurology. 1988;38:517–22.

    Article  CAS  PubMed  Google Scholar 

  47. Kelly AG. Unruptured intracranial aneurysms: screening and management. Continuum. 2014;20(2):387–98.

    PubMed  Google Scholar 

  48. Green MW. Secondary headaches. Contin Lifelong Learn Neurol. 2012;18(4):783–95.

    Article  Google Scholar 

  49. Barrett KM, Meschia JF. Genetic stroke syndromes. Continuum. 2014;20(2):339–411.

    Google Scholar 

  50. Lu-Emerson C, Eichler AF. Brain metastases. Contin Lifelong Learn Neurol. 2012;18(2):295–311.

    Article  Google Scholar 

  51. Rosenfeld MR, Pruit AA. Management of malignant gliomas and primary CNS lymphoma: standard care and future directions. Contin Lifelong Learn Neurol. 2012;18(2):406–15.

    Article  Google Scholar 

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Conflict of Interest

Dr. J. Ivan Lopez, Dr. Ashley Holdridge, and Dr. John Rothrock each declare no potential conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Correspondence to J. Ivan Lopez.

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This article is part of the Topical Collection on Uncommon and/or Unusual Headaches and Syndromes

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Lopez, J.I., Holdridge, A. & Rothrock, J.F. Hemiplegia and Headache: a Review of Hemiplegia in Headache Disorders. Curr Pain Headache Rep 19, 471 (2015). https://doi.org/10.1007/s11916-014-0471-y

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  • DOI: https://doi.org/10.1007/s11916-014-0471-y

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