Abstract
The most common scenario wherein the practicing neurologist is likely to encounter a patient with headache and hemiplegia will vary depending on his/her specific type of practice. A neurologist providing consultative service to an emergency department is far more likely to see patients with “secondary” headache and hemiplegia in the setting of either ischemic or hemorrhagic stroke than hemiplegia as a transient feature of a primary headache disorder. Neurologists subspecializing in headache medicine who practice in a tertiary referral headache clinic are more likely to encounter hemiplegic migraine, but even in that clinical setting hemiplegic migraine is by no means a frequent diagnosis. The acute onset of hemiplegia can be very frightening not only to the patient but also to the medical personnel. Given the abundance of mimicry, practitioners must judiciously ascertain the correct diagnosis as treatment may greatly vary depending on the cause of both headache and hemiplegia. In this review, we will address the most common causes of hemiplegia associated with headache.
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Ferro J, Canhao P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke. 2004;35(3):664–70.
Rasmussen BK, Olesen J. Symptomatic and nonsymptomatic headaches in a general population. Neurology. 1992;42:1225–31.
Mackey J. Evaluation and management of stroke in young adults. Continuum. 2014;20(2):352–69.
Vahedi K, Chabriat H, Levy C, et al. Migraine with aura and brain magnetic resonance imaging abnormalities in patients with CADASIL. Arch Neurol. 2004;61(8):1237–40.
Pavlakis SG, Phillips PC, DiMauro S, et al. Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome. Ann Neurol. 1984;16(4):481–8.
Runchey S, McGee S. Does this patient have a hemorrhagic stroke? Clinical findings distinguishing hemorrhagic stroke from ischemic stroke. JAMA. 2010;30:2280–6.
Viana M, Sprenger T, Andelova M, et al. The typical duration of migraine aura: a systematic review. Cephalalgia. 2013;33:483–90.
Ward T. Migraine diagnosis and pathophysiology. Contin Lifelong Learn Neurol. 2012;18(2):753–4.
The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33:629–808. This is the newest classification of headache disorders and everyone interested in headaches should be familiar with this classification.
Akerman S, Holland PR, Goadsby PJ. Diencephalic and brainstem mechanisms in migraine. Nat Rev Neurosci. 2011;12:570–84.
Zhang X, Levy D, Noseda R, et al. Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci. 2010;30:8807–14.
Eikerman-Haerter K. Spreading depolarizing may link migraine and stroke. Headache. 2014;54:1146–57. Insightful article on the link between migraine and stroke.
Tzouri C, Tehindrazanarivelo A, Iglesias S, et al. Case–control study of migraine and risk of ischemic stroke in young women. BMJ. 1995;310:830–3.
Buring J, Hebert P, Romero J, et al. Migraine and subsequent risk of stroke in the Physician’s Health Study. Arch Neurol. 1995;52:129–34.
Merikangas K, Fenton B, Cheng S, et al. Association between migraine and stroke in a large-scale epidemiological study of the United States. Arch Neurol. 1997;54:362–8.
Kurth T, Slomke M, Kase C, et al. Migraine, headache and the risk of stroke in women: a prospective study. Neurology. 2005;64:1020–6.
Headache Classification Committee of the International Headache Society. ICHD-II abbreviated pocket version. Cephalalgia. 2004;24 Suppl 1:1–160.
Russell MB, Ducros A. Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management. Lancet Neurol. 2011;10:457–70.
Heron SE, Dibbens LM. Role of PRRT2 in common paroxysmal neurological disorders: a gene with remarkable pleiotropy. J Med Genet. 2013;50:133–9.
Riant F, Roze E, Barbance C, et al. PRRT2 mutations cause hemiplegic migraine. Neurology. 2012;79:2122–4.
Marini C, Conti V, Mei D, et al. PRRT2 mutations in familial infantile seizures, paroxysmal dyskinesia, and hemiplegic migraine. Neurology. 2012;79:2109–14.
Pelzer N, de Vries B, Kamphorst J, et al. PRRT2 and hemiplegic migraine: a complex association. Neurology. 2014;83:288–90.
Fedak EM, Zumberge NA, Heyer GL. The diagnostic role for susceptibility-weighted MRI during sporadic hemiplegic migraine. Cephalalgia. 2013;0(0):1–6.
Hansen JM, Schytz HW, Larsen VA, et al. Hemiplegic migraine aura with cerebral hypoperfusion: imaging in the acute phase. Headache. 2011;51:1289–96.
Lizuka T, Takahashi Y, Sato M, et al. Neurovascular changes in prolonged migraine aura in FHM with a novel ATP1A2 gene mutation. J Neurol Neurosurg Psychiatry. 2011. doi:10.1136/jnnp-2011-300843.
Mourand I, Menjot de Champfleur N, Carra-Dalleiere C, et al. Perfusion-weighted imaging in persistent hemiplegic migraine. Neuroradiology. 2012;54:255–60.
Sugrue G, Bolster F, Crosbie I, Kavanagh E. Hemiplegic migraine: neuroimaging findings during a hemiplegic migraine attack. Headache. 2014;54:716–8.
Schwedt TJ, Zhou J, Dodick DW. Sporadic hemiplegic migraine w permanent neurologic deficits. Headache. 2014;54:163–6.
Shevel E. Arterial surgery for sporadic hemiplegic migraine: preliminary results. Br J Oral Maxillofac Surg. 2014;52:405–8.
Tentschert S, Wimmer R, Greisenegger S, Lang W, Lalouschek W. Headache at stroke onset in 2196 patients with ischemic stroke or transient ischemic attack. Stroke. 2005;36:e1–3.
Gorelick P, Hier D, Caplan L, et al. Headache in acute cerebrovascular disease. Neurology. 1986;36:1445–50.
Grindal A, Toole J. Headache and transient ischemic attacks. Stroke. 1974;5:603–6.
Jorgenson H, Jespersen H, Nakayama H, et al. Headache and stroke: the Copenhagen stroke study. Neurology. 1994;44:1793–7.
Evans R, Mitsias P. Headache at the onset of acute cerebral ischemia. Headache. 2009;49:902–8.
Fisher C. Headache in cerebrovascular disease. In: Vinken P, Bruyn G, editors. Handbook of clinical neurology, vol. 5. Amsterdam: North Holland Publishing; 1968. p. 124.
Medina J, Diamond S, Rubino S. Headaches in patients with transient ischemic attacks. Headache. 1975;15:194.
Edmeads J. The headaches of ischemic cerebrovascular disease. Headache. 1979;19:345–9.
Ferro J, Melo T, Oliveiro A, et al. A multivariate study of headache associated with ischemic stroke. Headache. 1995;35:315–9.
Pickard J, Mackenzie E, Harper A. Serotonin and prostaglandins: intracranial and extracranial effects with reference to migraine. In: Green R, editor. Current concepts in migraine research. New York: Raven; 1978. p. 101.
Murinova N, Krashin D, Lucas S. Vascular risk in migraineurs: interaction of endothelial and cortical excitability factors. Headache. 2012;54:583–90.
Silbert P, Mokri B, Schievink W. Headache and neck pain in spontaneous internal carotid and vertebral artery dissections. Neurology. 1995;45:1517–22.
Mokri B, Sundt T, House O. Spontaneous internal carotid dissection, hemicrania and Horner’s syndrome.
Girot M, Ferro JM, Canhao P, et al. Predictors of outcome in patients with cerebral venous thrombosis and intracerebral hemorrhage. Stroke. 2007;38(2):337–42.
Bousser M, Barnett H. Cerebral venous thrombosis. In: Barnett H, Mohr J, Stein B, et al., editors. Stroke: pathology, diagnosis and management. 2nd ed. New York: Churchill and Livingston; 1992. p. 522.
Bousser M, Chiras J, Sauron B, et al. Cerebral venous thrombosis: a review of 38 cases. Stroke. 1985;16:199–213.
Levine S, Twyman R, Gilman S. The role of anticoagulation in cavernous sinus thrombosis. Neurology. 1988;38:517–22.
Kelly AG. Unruptured intracranial aneurysms: screening and management. Continuum. 2014;20(2):387–98.
Green MW. Secondary headaches. Contin Lifelong Learn Neurol. 2012;18(4):783–95.
Barrett KM, Meschia JF. Genetic stroke syndromes. Continuum. 2014;20(2):339–411.
Lu-Emerson C, Eichler AF. Brain metastases. Contin Lifelong Learn Neurol. 2012;18(2):295–311.
Rosenfeld MR, Pruit AA. Management of malignant gliomas and primary CNS lymphoma: standard care and future directions. Contin Lifelong Learn Neurol. 2012;18(2):406–15.
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Dr. J. Ivan Lopez, Dr. Ashley Holdridge, and Dr. John Rothrock each declare no potential conflicts of interest.
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This article is part of the Topical Collection on Uncommon and/or Unusual Headaches and Syndromes
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Lopez, J.I., Holdridge, A. & Rothrock, J.F. Hemiplegia and Headache: a Review of Hemiplegia in Headache Disorders. Curr Pain Headache Rep 19, 471 (2015). https://doi.org/10.1007/s11916-014-0471-y
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DOI: https://doi.org/10.1007/s11916-014-0471-y