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Neurogenic Changes in the Upper Airway of Obstructive Sleep Apnoea

  • Sleep (M Thorpy, M Billiard, Section Editors)
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Abstract

Obstructive sleep apnoea (OSA) is linked to local neural injury that evokes airway muscle remodelling. The upper airway muscles of patients with OSA are exposed to intermittent hypoxia as well as vibration induced by snoring. A range of electrophysiological and other studies have established altered motor and sensory function of the airway in OSA. The extent to which these changes impair upper airway muscle function and their relationship to the progression of OSA remains undefined. This review will collate the evidence for upper airway remodelling in OSA, particularly the electromyographic changes in upper airway muscles of patients with OSA.

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Conflict of Interest

Julian P. Saboisky, Jane E. Butler, Billy L. Luu and Simon C. Gandevia have received a NHMRC grant.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Neuroscience Research Australia, University of New South Wales, Barker Street, PO Box 1165, Randwick Sydney, NSW, 2031, Australia

    Julian P. Saboisky, Jane E. Butler, Billy L. Luu & Simon C. Gandevia

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  1. Julian P. Saboisky
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  2. Jane E. Butler
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  3. Billy L. Luu
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Correspondence to Julian P. Saboisky.

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Saboisky, J.P., Butler, J.E., Luu, B.L. et al. Neurogenic Changes in the Upper Airway of Obstructive Sleep Apnoea. Curr Neurol Neurosci Rep 15, 12 (2015). https://doi.org/10.1007/s11910-015-0537-1

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