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Differential Diagnosis of Chorea

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Abstract

Chorea is a common movement disorder that can be caused by a large variety of structural, neurochemical (including pharmacologic), or metabolic disturbances to basal ganglia function, indicating the vulnerability of this brain region. The diagnosis is rarely indicated by the simple phenotypic appearance of chorea, and can be challenging, with many patients remaining undiagnosed. Clues to diagnosis may be found in the patient’s family or medical history, on neurologic examination, or upon laboratory testing and neuroimaging. Increasingly, advances in genetic medicine are identifying new disorders and expanding the phenotype of recognized conditions. Although most therapies at present are supportive, correct diagnosis is essential for appropriate genetic counseling, and ultimately, for future molecular therapies.

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Disclosure

Conflicts of interest: R.H. Walker: has received honoraria from Bioavail, and has received payment from Scienta and Intellyst.

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  1. Department of Neurology, James J. Peters Veterans Affairs Medical Center, Bronx, NY, 10468, USA

    Ruth H. Walker

  2. Department of Neurology, Mount Sinai School of Medicine, New York, NY, 10029, USA

    Ruth H. Walker

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Walker, R.H. Differential Diagnosis of Chorea. Curr Neurol Neurosci Rep 11, 385–395 (2011). https://doi.org/10.1007/s11910-011-0202-2

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