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Biomarkers in Occupational Asthma

  • Occupational Allergies (JA Poole, Section Editor)
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Work-related asthma is a common disorder among adult asthma patients, and in the case of occupational asthma, it is induced by workplace exposures.

Recent Findings

Occupational asthma provides an excellent model and benchmark for identifying and testing different allergy or inflammatory biomarkers associated with its inception or progression. Moreover, specific inhalation challenge with the incriminated agent represents an experimental setting to identify and validate potential systemic or local biomarkers. Some biomarkers are mainly blood-borne, while local airway biomarkers are derived from inflammatory or resident cells. Genetic and gene–environment interaction studies also provide an excellent framework to identify relevant profiles associated with the risk of developing these work-related conditions.

Summary

Despite significant efforts to identify clinically relevant inflammatory and genomic markers for occupational asthma, apart from the documented utility of airway inflammatory biomarkers, it remains elusive to define specific markers or signatures clearly associated with different endpoints or outcomes in occupational asthma.

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Authors and Affiliations

  1. Department of Allergy, La Paz Institute for Health Research (IdiPAZ), Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046, Madrid, Spain

    Javier Dominguez-Ortega, Pilar Barranco, Rosa Rodríguez-Pérez & Santiago Quirce

  2. CIBER de Enfermedades Respiratorias, CIBERES, Madrid, Spain

    Javier Dominguez-Ortega, Pilar Barranco, Rosa Rodríguez-Pérez & Santiago Quirce

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  1. Javier Dominguez-Ortega
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  2. Pilar Barranco
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  3. Rosa Rodríguez-Pérez
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  4. Santiago Quirce
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Correspondence to Javier Dominguez-Ortega.

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Drs. Dominguez-Ortega, Barranco, Rodríguez-Pérez, and Quirce declare no conflicts of interest relevant to this manuscript.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Occupational Allergies

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Dominguez-Ortega, J., Barranco, P., Rodríguez-Pérez, R. et al. Biomarkers in Occupational Asthma. Curr Allergy Asthma Rep 16, 63 (2016). https://doi.org/10.1007/s11882-016-0644-3

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