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Positive correlation between sarcopenia and elevation of neutrophil/lymphocyte ration in pathological stage IIIA (N2-positive) non-small cell lung cancer patients

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General Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript

A Correction to this article was published on 05 January 2019

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Abstract

Objective

Surgical indication in stage IIIA (N2) non-small cell lung cancer is still controversial. Hence, there is a need for the identification of predictors of the postoperative outcome in these patients. Although sarcopenia is expected to be a novel predictor of postoperative outcome in these patients, the underlying clinical features of sarcopenia have not been well investigated. Elevation of neutrophil/lymphocyte ratio indicates cancer-associated inflammation and depression of anticancer immunity. We analyzed the influence of sarcopenia on postoperative prognosis, and investigated the relationship between sarcopenia and neutrophil/lymphocyte ratio in patients with stage IIIA (N2) non-small cell lung cancer.

Methods

We retrospectively investigated 69 patients with stage IIIA (N2) non-small cell lung cancer. We used the L3 muscle index as a clinical measurement of sarcopenia, and divided patients into the sarcopenic (n = 21) and the non-sarcopenic group (n = 48). We then investigated the effect of sarcopenia on postoperative prognosis, and evaluated the correlation between sarcopenia and neutrophil/lymphocyte ratio.

Results

This study included 47 males and 22 females. Univariate analysis revealed that sarcopenia, performance status, and serum cytokeratin-19 fragment level were predictors of poor prognosis; multivariate analysis revealed that performance status and sarcopenia were independent predictors of poor prognosis. The presence of sarcopenia was significantly correlated with neutrophil/lymphocyte ratio elevation.

Conclusions

Sarcopenia is a novel predictor of poor prognosis in patients with stage IIIA (N2) non-small cell lung cancer. Neutrophil/lymphocyte ratio elevation might be the reason for poor prognosis in sarcopenic patients.

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Change history

  • 05 January 2019

    In the original publication of the article, the title was incorrectly published as ?Positive correlation between sarcopenia and elevation of neutrophil/lymphocyte ratio in pathological stage.

  • 05 January 2019

    In the original publication of the article, the title was incorrectly published as ���Positive correlation between sarcopenia and elevation of neutrophil/lymphocyte ratio in pathological stage.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Osaka City University Hospital, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan

    Takuma Tsukioka, Nobuhiro Izumi, Shinjiro Mizuguchi, Chung Kyukwang, Hiroaki Komatsu, Michihito Toda, Kantaro Hara, Hikaru Miyamoto & Noritoshi Nishiyama

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  1. Takuma Tsukioka
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  2. Nobuhiro Izumi
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  3. Shinjiro Mizuguchi
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Correspondence to Takuma Tsukioka.

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Tsukioka, T., Izumi, N., Mizuguchi, S. et al. Positive correlation between sarcopenia and elevation of neutrophil/lymphocyte ration in pathological stage IIIA (N2-positive) non-small cell lung cancer patients. Gen Thorac Cardiovasc Surg 66, 716–722 (2018). https://doi.org/10.1007/s11748-018-0985-z

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