Abstract
We report an extremely rare case of minute localized malignant pleural mesothelioma (LMPM) coexisting with multiple lung adenocarcinomas in a 64-year-old woman without a history of smoking or asbestos exposure. A computed tomography scan of the chest displayed total five ground-glass opacities in the lung. Transbronchial lung biopsy from a ground-glass opacity in the posterior segment revealed a bronchioloalveolar carcinoma. With a diagnosis of primary lung cancer, right upper lobectomy and wedge resection of the right lower lobe with systematic lymph node dissection was performed using video-assisted thoracoscopic surgery. Incidentally, a minute gray-white nodule measuring 6 mm was detected on the visceral pleural surface of the right upper lobe. The postoperative histological diagnosis was minute LMPM coexisting with multiple adenocarcinomas.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Rusch VW. Mesothelioma and less common pleural tumors. In: Person FG, Cooper JD, Deslauriers J, Ginsberg RJ, Hiebert CA, Patterson GA, et al, editors. Thoracic surgery, 2nd edn. Philadelphia: Churchill Livingstone; 2002. p. 1241–1263.
Allen TC, Cagle PT, Churg AM, Colby TV, Gibbs AR, Hammar SP, et al. Localized malignant mesothelioma. Am J Surg Pathol 2005;29:866–873.
Crotty TB, Myers JL, Katzenstein AL, Tazelaar HD, Swensen SJ, Churg A. Localized malignant mesothelioma: a clinicopathologic and flow cytometric study. Am J Surg Pathol 1994; 18:357–363.
Hirano H, Takeda S, Sawabata Y, Okumura Y, Maeda H, Hanibuchi M, et al. Localized pleural malignant mesothelioma. Pathol Int 2003;53:616–621.
England DM, Hochholzer L, McCarthy MJ. Localized benign and malignant fibrous tumors of the pleura: a clinicopathologic review of 223 cases. Am J Surg Pathol 1989;13:640–658.
Attanoos RL, Griffin A, Gibbs AR. The use of immunohistochemistry in distinguishing reactive from neoplastic mesothelium: a novel use for desmin and comparative evaluation with epithelial membrane antigen, p53, platelet-derived growth factor-receptor, P-glycoprotein and Bcl-2. Histopathology 2003;43:231–238.
Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 2003;21: 2636–2644.
Erkiliç S, Sari I, Tunçözgür B. Localized pleural malignant mesothelioma. Pathol Int 2001;51:812–815.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Maeda, R., Isowa, N., Onuma, H. et al. Minute localized malignant pleural mesothelioma coexisting with multiple adenocarcinomas. Gen Thorac Cardiovasc Surg 58, 91–94 (2010). https://doi.org/10.1007/s11748-009-0466-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11748-009-0466-5