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Evaluation on biocompatibility of biomedical polyurethanes with different hard segment contents

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Abstract

In this paper, polyurethane (PU) materials with different contents of hard segment (20%, 25%, 30%) were prepared based on hexamethylene diisocyanate and polycarbonate diols by solution polymerization. The obtained polycarbonate-urethane (PCU) elastomers were characterized by very good hydrophobic property and excellent resistance to hydrolysis. Hemolysis, recalification time and platelet-rich plasma adhesion were used to evaluate the blood compatibility of the materials. L929 cells cultured with leach liquor of these PU membranes were selected to perform the cytotoxicity experiments. The results indicate that the hemolysis rates of PU membranes are all less than 5%, which can meet the requirement of the national standards for biomaterials. However, compared with 20% and 30% groups, the recalification time of the sample containing 25% hard segment is longer, while the number of platelet adhesion is less. Additionally, cells cultured in the leach liquor of PU membranes with 25% hard segment proliferated relatively more thriving, meaning that this proportion of the material has the lowest cytotoxicity.

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Authors and Affiliations

  1. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China

    Dai-Wei Ma, Rong Zhu, Yi-Yu Wang, Zong-Rui Zhang & Xin-Yu Wang

  2. Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070, China

    Dai-Wei Ma, Rong Zhu, Yi-Yu Wang, Zong-Rui Zhang & Xin-Yu Wang

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  1. Dai-Wei Ma
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  2. Rong Zhu
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  3. Yi-Yu Wang
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  4. Zong-Rui Zhang
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  5. Xin-Yu Wang
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Correspondence to Xin-Yu Wang.

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Ma, DW., Zhu, R., Wang, YY. et al. Evaluation on biocompatibility of biomedical polyurethanes with different hard segment contents. Front. Mater. Sci. 9, 397–404 (2015). https://doi.org/10.1007/s11706-015-0316-6

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  • DOI: https://doi.org/10.1007/s11706-015-0316-6

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