Abstract
Magnetic Fe3O4 and mesoporous silica core-shell nanospheres with tunable size from 110–800 nm were synthesized via a one step self-assembly method. The morphological, structural, textural, and magnetic properties were well-characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, N2 adsorption-desorption and magnetometer. These nanocomposites, which possess high surface area, large pore volume and well-defined pore size, exhibit two dimensional hexagonal (P6mm) mesostructures. Interestingly, magnetic core and mesoporous silica shell nanocomposites with large void pore (20 nm) on the shell were generated by increasing the ratio of ethanol/water. Additionally, the obtained nanocomposites combined magnetization response and large void pore, implying the possibility of applications in drug/gene targeting delivery. The cell internalization capacity of NH2-functionalized nanocomposites in the case of cancer cells (HeLa cells) was exemplified to demonstrate their nano-medicine application.
Similar content being viewed by others
References
Lu A H, Schmidt W, Matoussevitch N, Bonnemann H, Spliethoff B, Tesche B, Bill E, Kiefer W, Schuth F. Nanoengineering of a magnetically separable hydrogenation catalyst. Angewandte Chemie International Edition, 2004, 43(33): 4303–4306
Liu J, Qiao S Z, Hu Q H, Lu G Q. Magnetic nanocomposites with mesoporous structures: Synthesis and applications. Small, 2011, 7(4): 425–443
Guerrero-Martínez A, Pérez-Juste J, Liz-Marzán L M. Recent progress on silica coating of nanoparticles and related nanomaterials. Advanced Materials, 2010, 22(11): 1182–1195
Wu P G, Zhu J H, Xu Z H. Template-assisted synthesis of mesoporous magnetic nanocomposite particles. Advanced Functional Materials, 2004, 14(4): 345–351
Yi D K, Lee S S, Papaefthymiou G C, Ying J Y. Nanoparticle architectures templated by SiO2/Fe2O3 nanocomposites. Chemistry of Materials, 2006, 18(3): 614–619
Kim J, Lee J E, Lee J, Yu J H, Kim B C, An K, Hwang Y, Shin C H, Park J G, Hyeon T. Magnetic fluorescent delivery vehicle using uniform mesoporous silica spheres embedded with monodisperse magnetic and semiconductor nanocrystals. Journal of the American Chemical Society, 2006, 128(3): 688–689
Kim J, Kim H S, Lee N, Kim T, Kim H, Yu T, Song I C, Moon W K, Hyeon T. Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery. Angewandte Chemie International Edition, 2008, 47(44): 8438–8441
Liong X, Lu J, Kovochich M, Xia T, Ruehm S G, Nel A E, Tamanoi F, Zink J I. Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. ACS Nano, 2008, 2(5): 889–896
Zhang L, Qiao S Z, Jin Y G, Yang H G, Budihartono S, Stahr F, Yan Z F, Wang X L, Hao Z P, Lu G Q. Fabrication and size-selective bioseparation of magnetic silica nanospheres with highly ordered periodic mesostructure. Advanced Functional Materials, 2008, 18(20): 3203–3212
Lin Y S, Haynes C L. Synthesis and characterization of biocompatible and size-tunable multifunctional porous silica nanoparticles. Chemistry of Materials, 2009, 21(17): 3979–3986
Ruiz-Hernandez E, Lopez-Noriega A, Arcos D, Izquierdo-Barba I, Terasaki O, Vallet-Regi M. Aerosol-assisted synthesis of magnetic mesoporous silica spheres for drug targeting. Chemistry of Materials, 2007, 19(14): 3455–3463
Zhang L, Zhang F, Dong W F, Song J F, Huo Q S, Sun H B. Magnetic-mesoporous Janus nanoparticles. Chemical Communications, 2011, 47(4): 1225–1227
Zhao Y, Lin L N, Lu Y, Gao H L, Chen S F, Yang P, Yu S H. Synthesis of tunable theranostic Fe3O4@mesoporous silica nanospheres for biomedical applications. Advanced Healthcare Materials, 2012, 1(3): 327–331
Liu Q, Zhang J X, Xia W L, Gu H C. Magnetic field enhanced cell uptake efficiency of magnetic silica mesoporous nanoparticles. Nanoscale, 2012, 4(11): 3415–3421
Liu J, Wang B, Hartono S B, Liu T T, Kantharidis P, Middelberg A P J, Lu G Q, He L Z, Qiao S Z. Magnetic silica spheres with large nanopores for nucleic acid adsorption and cellular uptake. Biomaterials, 2012, 33(3): 970–978
Wan Y, Zhao D Y. On the controllable soft-templating approach to mesoporous silicates. Chemical Reviews, 2007, 107(7): 2821–2860
Deng Y, Qi D, Deng C, Zhang X, Zhao D Y. Superparamagnetic high-magnetization microspheres with an Fe3O4@SiO2 core and perpendicularly aligned mesoporous SiO2 shell for removal of microcystins. Journal of the American Chemical Society, 2008, 130(1): 28–29
Wang P, Shi Q H, Shi Y F, Clark K K, Stucky G D, Keller A A. Magnetic permanently confined micelle arrays for treating hydrophobic organic compound contamination. Journal of the American Chemical Society, 2009, 131(1): 182–188
Hartono S B, Gu W Y, Kleitz F, Liu J, He L Z, Middelberg A P J, Yu C Z, Lu G Q, Qiao S Z. Poly-L-lysine functionalized large pore cubic mesostructured silica nanoparticles as biocompatible carriers for gene delivery. ACS Nano, 2012, 6(3): 2104–2117
Na H K, Kim M H, Park K, Ryoo R S, Lee K E, Jeon H, Ryoo R, Hyeon C B, Min D H. Efficient functional delivery of siRNA using mesoporous silica nanoparticles with ultralarge pores. Small, 2012, 8(11): 1752–1761
Huang X L, Li L L, Liu T L, Hao N J, Liu H Y, Chen D, Tang F Q. The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo. ACS Nano, 2011, 5(7): 5390–5399
Zhao W R, Zhang H T, Chang S, Gu J L, Li Y S, Li L, Shi J L. An organosilane route to mesoporous silica nanoparticles with tunable particle and pore sizes and their anticancer drug delivery behavior. RSC Advances, 2012, 2(12): 5105–5107
Chen Z T, Niu D C, Li Y S, Shi J L. One-step approach to synthesize hollow mesoporous silica spheres co-templated by an amphiphilic block copolymer and cationic surfactant. RSC Advances, 2013, 3(19): 6767–6770
Niu D C, Ma Z, Li Y S, Shi J L. Synthesis of core-shell structured dual-mesoporous silica spheres with tunable pore size and controllable shell thickness. Journal of the American Chemical Society, 2010, 132(43): 15144–15147
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Liu, T., Liu, L., Liu, J. et al. Fe3O4 encapsulated mesoporous silica nanospheres with tunable size and large void pore. Front. Chem. Sci. Eng. 8, 114–122 (2014). https://doi.org/10.1007/s11705-014-1413-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11705-014-1413-2