Abstract
Recent studies have shown that the systematic and repetitive observation of actions belonging to the experiential human motor repertoire without verbal facilitation enhances the recovery of verbs in non fluent aphasia. However, it is still an open question whether this approach extends its efficacy also on discourse productivity by improving the retrieval of other linguistic units (i.e. nouns, sentences, content words). Moreover, nothing is known regarding the neural substrates which support the language recovery process due to action observation treatment.In the present study, ten non fluent aphasics were presented with two videoclips (real everyday life context vs. familiar pantomimed context), each video for six consecutive weeks (Monday to Friday, weekend off). During the treatment, they were asked to observe each video and to describe it without verbal facilitation from the therapist. In all patients, language measures were collected before and at the end of treatment. Before and after each treatment condition (real vs. pantomimed context), each subject underwent a resting state fMRI. After the treatment, significant changes in functional connectivity were found in right sensory-motor networks which were accompanied by a significant improvement for the different linguistic units in the real context condition. On the contrary, the language recovery obtained in the pantomimed context did not match any functional modification. The evidence for a recruitment of the sensory-motor cortices during the observation of actions embedded in real context suggests to potentially enhance language recovery in non fluent aphasia through a simulation process related to the sensory-motor properties of actions.
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References
Aziz-Zadeh, L., Koski, L., Zaidel, E., Mazziotta, J., & Iacoboni, M. (2006). Lateralization of the human mirror neuron system. The Journal of Neuroscience, 26(11), 2964–2970. doi:10.1523/JNEUROSCI.2921-05.2006.
Barsalou, L. W. (1999). Perceptions of perceptual symbols. Behavioral and Brain Sciences, 22(04), 637–660. doi:10.1017/S0140525X99532147.
Barsalou, L. W., Simmons, W. K., Barbey, A. K., & Wilson, C. D. (2003). Grounding conceptual knowledge in modality-specific systems. Trends in Cognitive Sciences, 7(2), 84–91. doi:10.1016/S1364-6613(02)00029-3.
Beauchamp, M. S., Lee, K. E., Haxby, J. V., & Martin, A. (2002). Parallel visual motion processing streams for manipulable objects and human movements. Neuron, 34(1), 149–159. doi:10.1016/S0896-6273(02)00642-6.
Bedny, M., Caramazza, A., Grossman, E., Pascual-Leone, A., & Saxe, R. (2008). Concepts are more than percepts: the case of action verbs. The Journal of Neuroscience, 28(44), 11347–11353. doi:10.1523/JNEUROSCI.3039-08.2008.
Behzadi, Y., Restom, K., Liau, J., & Liu, T. T. (2007). A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. NeuroImage, 37, 90–101.
Bellelli, G., Buccino, G., Bernardini, B., Padovani, A., & Trabucchi, M. (2010). Action observation treatment improves recovery of postsurgical orthopedic patients: evidence for a top-down effect? Archives of Physical Medicine and Rehabilitation, 91(10), 1489–1494. doi:10.1016/j.apmr.2010.07.013.
Bernardis, P., & Gentilucci, M. (2006). Speech and gesture share the same communication system. Neuropsychologia, 44(2), 178–190. doi:10.1016/j.neuropsychologia.2005.05.007.
Binkofski, F., & Buccino, G. (2006). The role of ventral premotor cortex in action execution and action understanding. Journal of Physiology, Paris, 99(4), 396–405. doi:10.1016/j.jphysparis.2006.03.005.
Binkofski, F., Buccino, G., Stephan, K. M., Rizzolatti, G., Seitz, R. J., & Freund, H. J. (1999). A parieto-premotor network for object manipulation: evidence from neuroimaging. Experimental Brain Research, 128(1–2), 210–213. doi:10.1007/s002210050838.
Birn, R. M., Diamond, J. B., Smith, M. A., & Bandettini, P. A. (2006). Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI. NeuroImage, 31(4), 1536–1548. doi:10.1016/j.neuroimage.2006.02.048.
Bonifazi, S., Tomaiuolo, F., Altoè, G., Ceravolo, M. G., Provinciali, L., & Marangolo, P. (2013). Action observation as a useful approach for enhancing recovery of verb production: new evidence from aphasia. European Journal of Physical and Rehabilitation Medicine, 49(4), 473–481.
Boulenger, V., Hauk, O., & Pulvermüller, F. (2009). Grasping ideas with the motor system: semantic somatotopy in idiom comprehension. Cerebral cortex,19(8), 1905–1914. doi:10.1093/cercor/bhn217
Buccino, G., Binkofski, F., Fink, G. R., Fadiga, L., Fogassi, L., Gallese, V., & Freund, H. J. (2001). Action observation activates premotor and parietal areas in a somatotopic manner: an fMRI study. European Journal of Neuroscience, 13(2), 400–404. doi:10.1111/j.1460-9568.2001.01385.x.
Buccino, G., Lui, F., Canessa, N., Patteri, I., Lagravinese, G., Benuzzi, F., & Rizzolatti, G. (2004). Neural circuits involved in the recognition of actions performed by nonconspecifics: an fMRI study. Journal of Cognitive Neuroscience, 16(1), 114–126. doi:10.1162/089892904322755601.
Buccino, G., Gatti, R., Giusti, M. C., Negrotti, A., Rossi, A., Calzetti, S., & Cappa, S. F. (2011). Action observation treatment improves autonomy in daily activities in Parkinson's disease patients: results from a pilot study. Movement Disorders, 26(10), 1963–1964. doi:10.1002/mds.23745.
Bullmore, E. T., & Sporns, O. (2009). Complex brain networks: graph theoretical analysis of structural and functional systems. Nature Reviews. Neuroscience, 10(3), 186–189. doi:10.1038/nrn2575.
Buxbaum, L. J., Kyle, K. M., & Menon, R. (2005). On beyond mirror neurons: internal representations subserving imitation and recognition of skilled object-related actions in humans. Cognitive Brain Research, 25(1), 226–239. doi:10.1016/j.cogbrainres.2005.05.014.
Calvo-Merino, B., Glaser, D. E., Grèzes, J., Passingham, R. E., & Haggard, P. (2005). Action observation and acquired motor skills: an FMRI study with expert dancers. Cerebral Cortex, 15(8), 1243–1249. doi:10.1093/cercor/bhi007.
Casile, A., Caggiano, V., & Ferrari, P. F. (2011). The mirror neuron system: a fresh view. The Neuroscientist, 17(5), 524–538. doi:10.1177/1073858410392239.
Chang, C., & Glover, G. H. (2009). Effects of model-based physiological noise correction on default mode network anti-correlations and correlations. NeuroImage, 47(4), 1448–1459. doi:10.1016/j.neuroimage.2009.05.012.
Chen, W., Ye, Q., Ji, X., Zhang, S., Yang, X., et al. (2015). Mirror neuron system based tharpy for aphasia rehabilitation. Frontiers in Psychology, 6:doi:10.3389/fpsyg.2015.01665
Ciurli, P., Marangolo, P., Basso, A. (1996). Esame del Linguaggio II, Organizzazioni Speciali Firenze.
Creem-Regehr, S. H. (2009). Sensory-motor and cognitive functions of the human posterior parietal cortex involved in manual actions. Neurobiology of Learning and Memory, 91(2), 166–171. doi:10.1016/j.nlm.2008.10.004.
Davis, M. H., Meunier, F., & Marslen-Wilson, W. D. (2004). Neural responses to morphological, syntactic, and semantic properties of single words: an fMRI study. Brain and Language, 89(3), 439–449. doi:10.1016/S0093-934X(03)00471-1.
De Lange, F. P., Spronk, M., Willems, R. M., Toni, I., & Bekkering, H. (2008). Complementary systems for understanding action intentions. Current Biology, 18(6), 454–457. doi:10.1016/j.cub.2008.02.057.
De Renzi, E., & Vignolo, L. A. (1962). Token test: a sensitive test to detect receptive disturbances in aphasics. Brain, 85, 665–678. doi:10.1093/brain/85.4.665.
Decety, J., Perani, D., Jeannerod, M., Bettinardi, V., Tadary, B., Woods, R., et al. (1994). Mapping motor representations with positron emission tomography. Nature, 371, 600–602. doi:10.1038/371600a0.
Decety, J., Grezes, J., Costes, N., Perani, D., Jeannerod, M., Procyk, E., et al. (1997). Brain activity during observation of actions. Brain, 120, 1763–1777. doi:10.1093/brain/120.10.1763.
Draper, N. R., & Smith, H. (1998). Applied regression analysis. Wiley Interscience. ISBN: 978–0–471-17082-2
Ertelt, D., & Binkofski, F. (2012). Action observation as a tool for neurorehabilitation to moderate motor deficits and aphasia following stroke. Neural Regeneration Research, 7(26), 2063–2075. doi:10.3969/j.issn.1673-5374.2012.26.008.
Ertelt, D., Small, S., Solodkin, A., Dettmers, C., McNamara, A., Binkofski, F., & Buccino, G. (2007). Action observation has a positive impact on rehabilitation of motor deficits after stroke. NeuroImage, 36, 164–173. doi:10.1016/j.neuroimage.2007.03.043.
Ertelt, D., Hemmelmann, C., Dettmers, C., Ziegler, A., & Binkofski, F. (2012). Observation and execution of upper-limb movements as a tool for rehabilitation of motor deficits in paretic stroke patients: protocol of a randomized clinical trial. BMC Neurology, 12(1), 12–42. doi:10.1186/1471-2377-12-42.
Fadiga, L., Fogassi, L., Pavesi, G., & Rizzolatti, G. (1995). Motor facilitation during action observation: a magnetic stimulation study. Journal of Neurophysiology, 73(6), 2608–2611.
Fadiga, L., Craighero, L., Buccino, G., & Rizzolatti, G. (2002). Speech listening specifically modulates the excitability of tongue muscles: a TMS study. European Journal of Neuroscience, 15(2), 399–402. doi:10.1046/j.0953-816x.2001.01874.x.
Fischer, M. H., & Zwaan, R. A. (2008). Embodied language: a review of the role of the motor system in language comprehension. The Quarterly Journal of Experimental Psychology, 61(6), 825–850. doi:10.1080/17470210701623605.
Franceschini, M., Agosti, M., Cantagallo, A., Sale, P., Mancuso, M., & Buccino, G. (2010). Mirror neurons: action observation treatment as a tool in stroke rehabilitation. European Journal of Physical and Rehabilitation Medicine, 46(4), 517–523.
Gallese, V., & Lakoff, G. (2005). The brain's concepts: the role of the sensory-motor system in conceptual knowledge. Cognitive Neuropsychology, 22(4), 455–479. doi:10.1080/02643290442000310.
Gazzola, V., & Keysers, C. (2009). The observation and execution of actions share motor and somatosensory voxels in all tested subjects: single-subject analyses of unsmoothed fMRI data. Cerebral Cortex, 19(6), 1239–1255. doi:10.1093/cercor/bhn181.
Gazzola, V., Rizzolatti, G., Wicker, B., & Keysers, C. (2007). The anthropomorphic brain: the mirror neuron system responds to human and robotic actions. NeuroImage, 35(4), 1674–1684. doi:10.1016/j.neuroimage.2007.02.003.
Gentilucci, M., & Dalla Volta, R. (2008). Spoken language and arm gestures are controlled by the same motor control system. The Quarterly Journal of Experimental Psychology, 61(6), 944–957. doi:10.1080/17470210701625683.
Gentilucci, M., Dalla Volta, R., & Gianelli, C. (2008). When the hands speak. Journal of Physiology, Paris, 102(1), 21–30. doi:10.1016/j.jphysparis.2008.03.002.
Gili, T., Saxena, N., Diukova, A., Murphy, K., Hall, J. E., & Wise, R. G. (2013). The thalamus and brainstem act as key hubs in alterations of human brain network connectivity induced by mild propofol sedation. The Journal of Neuroscience, 33(9), 4024–4031. doi:10.1523/JNEUROSCI.3480-12.2013.
Glover, G. H., Li, T. Q., & Ress, D. (2000). Image-based method for retrospective correction of physiological motion effects in fMRI: RETROICOR. Magnetic Resonance in Medicine, 44(1), 162–167. doi:10.1002/1522-2594(200007)44:1.
Goelman, G., Gordon, N., & Bonne, O. (2014). Maximazing negative correlations in resting-state functional connectivity MRI by time-leg. PloS One, 9(11), e111554. doi:10.1371/journal.pone.0111554.
Hadar, U. (1989). Two types of gesture and their role in speech production. Journal of Language and Social Psychology, 8(3–4), 221–228. doi:10.1177/0261927X8983004.
Hadar, U., Wenkert-Olenik, D., Krauss, R., & Soroker, N. (1998). Gesture and the processing of speech: neuropsychological evidence. Brain and Language, 62(1), 107–126. doi:10.1006/brln.1997.1890.
Hauk, O., Shtyrov, Y., & Pulvermüller, F. (2006). The sound of actions as reflected by mismatch negativity: rapid activation of cortical sensory–motor networks by sounds associated with finger and tongue movements. European Journal of Neuroscience, 23(3), 811–821. doi:10.1111/j.1460-9568.2006.04586.x.
Hayasaka, S., & Laurienti, P. J. (2010). Comparison of characteristics between region-and voxel-based network analyses in resting-state fMRI data. NeuroImage, 50(2), 499–508. doi:10.1016/j.neuroimage.2009.12.051.
Hayasaka, S., & Nichols, T. E. (2003). Validating cluster size inference: random field and permutation methods. NeuroImage, 20(4), 2343–2356. doi:10.1016/j.neuroimage.2003.08.003.
Iacoboni, M., Molnar-Szakacs, I., Gallese, V., Buccino, G., Mazziotta, J. C., & Rizzolatti, G. (2005). Grasping the intentions of others with one's own mirror neuron system. PLoS Biology, 3(3), e79. doi:10.1371/journal.pbio.0030079.
Jirak, D., Menz, M. M., Buccino, G., Borghi, A. M., & Binkofski, F. (2010). Grasping language–a short story on embodiment. Consciousness and Cognition, 19(3), 711–720. doi:10.1016/j.concog.2010.06.020.
Kable, J. W., Lease-Spellmeyer, J., & Chatterjee, A. (2002). Neural substrates of action event knowledge. Journal of Cognitive Neuroscience, 14(5), 795–805. doi:10.1162/08989290260138681.
Kemmerer, D., Castillo, J. G., Talavage, T., Patterson, S., & Wiley, C. (2008). Neuroanatomical distribution of five semantic components of verbs: evidence from fMRI. Brain and Language, 107(1), 16–43. doi:10.1016/j.bandl.2007.09.003.
Krauss, R. M., & Hadar, U. (1999). The role of speech-related arm/hand gestures in word retrieval. Gesture, speech, and sign, 93. doi:10.1093/acprof:oso/9780198524519.003.0006
Liuzza, M. T., Candidi, M., & Aglioti, S. M. (2011). Do not resonate with actions: sentence polarity modulates cortico-spinal excitability during action-related sentence reading. PloS One, 6(2), e16855. doi:10.1371/journal.pone.0016855.
Liuzzi, G., Freundlieb, N., Ridder, V., Hoppe, J., Heise, K., Zimerman, M., & Hummel, F. C. (2010). The involvement of the left motor cortex in learning of a novel action word lexicon. Current Biology, 20(19), 1745–1751. doi:10.1016/j.cub.2010.08.034.
Loban, W. (1966). Language ability: Grades seven, eight, and nine. Washington, DC: Government Printing Office.
Lohmann, G., Margulies, D. S., Horstmann, A., Pleger, B., Lepsien, J., Goldhahn, D., et al. (2010). Eigenvector centrality mapping for analyzing connectivity patterns in fMRI data of the human brain. PloS one,5(4), e10232-e10232. doi:10.1371/journal.pone.0010232
Marangolo, P., Bonifazi, S., Tomaiuolo, F., Craighero, L., Coccia, M., Altoè, G., & Cantagallo, A. (2010). Improving language without words: first evidence from aphasia. Neuropsychologia, 48(13), 3824–3833. doi:10.1016/j.neuropsychologia.2010.09.025.
Marangolo, P., Cipollari, S., Fiori, V., Razzano, C., & Caltagirone, C. (2012). Walking but not barking improves verb recovery: implications for action observation treatment in aphasia rehabilitation. PloS One, 7(6), e38610. doi:10.1371/journal.pone.0038610.
Martin, A., & Chao, L. L. (2001). Semantic memory and the brain: structure and processes. Current Opinion in Neurobiology, 11(2), 194–201.
Martin, A., Haxby, J. V., Lalonde, F. M., Wiggs, C. L., & Ungerleider, L. G. (1995). Discrete cortical regions associated with knowledge of color and knowledge of action. Science, 270(5233), 102–105. doi:10.1126/science.270.5233.102.
Martin, A., Ungerleider, L. G., & Haxby, J. V. (2000). Category specificity and the brain: the sensory/motor model of semantic representations of objects. The new Cognitive Neurosciences, 2, 1023–1036. doi:10.1146/annurev.psych.60.110707.163532.
McClelland, J. L., & Rogers, T. T. (2003). The parallel distributed processing approach to semantic cognition. Nature Reviews Neuroscience, 4(4), 310–322. doi:10.1038/mrm1076.
McNeill, D. (1992). Hand and mind: What gestures reveal about thought. University of Chicago Press.
Meister, I. G., Sparing, R., Foltys, H., Gebert, D., Huber, W., Töpper, R., & Boroojerdi, B. (2006). Functional connectivity between cortical hand motor and language areas during recovery from aphasia. Journal of the Neurological Sciences, 247(2), 165–168. doi:10.1016/j.jns.2006.04.003.
Miceli, G., Laudanna, A., Burani, C., & Capasso, R. (1994). Batteria per l’analisi dei deficit afasici BADA. Roma, Italy: CEPSAG, Policlinico Gemelli, Università Cattolica del Sacro Cuore.
Michel, G. F., Babik, I., Nelson, E. L., Campbell, J. M., & Marcinowski, E. C. (2013). How the development of handedness could contribute to the development of language. Developmental Psychobiology, 55(6), 608–620. doi:10.1002/dev.21121.
Nakata, H., Sakamoto, K., Ferretti, A., Perrucci, M. G., Del Gratta, C., Kakigi, R., & Romani, G. L. (2008). Somato-motor inhibitory processing in humans: an event-related functional MRI study. NeuroImage, 39(4), 1858–1866. doi:10.1016/j.neuroimage.2007.10.041.
Newman, M. E. J. (2014). Analysis of weighted netowrks. Physical Review E, 70, 056131. doi:10.1103/PhysRevE.70.056131.
Nichols, T. E., & Holmes, A. P. (2002). Nonparametric permutation tests for functional neuroimaging: a primer with examples. Human Brain Mapping, 15(1), 1–25. doi:10.1002/hbm.1058.
Noppeney, U. (2008). The neural systems of tool and action semantics: a perspective from functional imaging. Journal of Physiology, Paris, 102(1), 40–49. doi:10.1016/j.jphysparis.2008.03.009.
Ocampo, B., & Kritikos, A. (2010). Placing actions in context: motor facilitation following observation of identical and non-identical manual acts. Experimental Brain Research, 201(4), 743–751. doi:10.1007/s00221-009-2089-6.
Orsini, A., Grossi, D., Capitani, E., Laiacona, M., Papagno, C., & Vallar, G. (1987). Verbal and spatial immediate memory span: normative data from 1355 adults and 1112 children. The Italian Journal of Neurological Sciences, 8(6), 537–548. doi:10.1007/BF02333660.
Osiurak, F., Jarry, C., Baltenneck, N., Boudin, B., & Le Gall, D. (2012). Make a gesture and I will tell you what you are miming. Pantomime recognition in healthy subjects. Cortex, 48(5), 584–592. doi:10.1016/j.cortex.2011.01.007.
Papo, D., Buldù, J. M., Boccaletti, S., & Bullmore, E. T. (2014). Complex network theory and the brain. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 369, 20130520. doi:10.1098/rstb.2013.0520.
Patterson, K., Nestor, P. J., & Rogers, T. T. (2007). Where do you know what you know? The representation of semantic knowledge in the human brain. Nature Reviews Neuroscience, 8(12), 976–987. doi:10.1038/nrn2277.
Power, J. D., Mitra, A., Laumann, T. O., Snyder, A. Z., Schlaggar, B. L., & Petersen, S. E. (2014). Methods to detect, characterize, and remove motion artifact in resting state fMRI. NeuroImage, 84, 320–341.
Pulvermüller, F. (1999). Words in the brain's language. Behavioral and Brain Sciences, 22(02), 253–279. doi:10.1017/S0140525X9900182X.
Pulvermüller, F., Hauk, O., Nikulin, V. V., & Ilmoniemi, R. J. (2005). Functional links between motor and language systems. European Journal of Neuroscience, 21(3), 793–797. doi:10.1111/j.1460-9568.2005.03900.x.
Revill, K. P., Aslin, R. N., Tanenhaus, M. K., & Bavelier, D. (2008). Neural correlates of partial lexical activation. Proceedings of the National Academy of Sciences, 105(35), 13111–13115. doi:10.1073/pnas.0807054105.
Rizzolatti, G., & Arbib, M. A. (1998). Language within our grasp. Trends in Neurosciences, 21(5), 188–194. doi:10.1016/S0166-2236(98)01260-0.
Rizzolatti, G., & Craighero, L. (2004). The mirror-neuron system. Annual Review of Neuroscience, 27, 169–192. doi:10.1146/annurev.neuro.27.070203.144230.
Rizzolatti, G., & Fogassi, L. (2014). The mirror mechanism: recent findings and perspectives. Philosophical Transactions of the Royal Society, B: Biological Sciences, 369(1644), 20130420. doi:10.1098/rstb.2013.0420.
Rizzolatti, G., Gentilucci, M., Camarda, R. M., Gallese, V., Luppino, G., Matelli, M., & Fogassi, L. (1990). Neurons related to reaching-grasping arm movements in the rostral part of area 6 (area 6aβ). Experimental Brain Research, 82(2), 337–350. doi:10.1007/BF00231253.
Rizzolatti, G., Fadiga, L., Matelli, M., Bettinardi, V., Paulesu, E., Perani, D., & Fazio, F. (1996). Localization of grasp representations in humans by PET: 1. Observation versus execution. Experimental Brain Research, 111(2), 246–252. doi:10.1007/BF00227301.
Rizzolatti, G., Fadiga, L., Fogassi, L., & Gallese, V. (1999). Resonance behaviors and mirror neurons. Archives Italiennes de Biologie, 137(2), 85–100.
Rizzolatti, G., Fogassi, L., & Gallese, V. (2000). Cortical mechanisms subserving object grasping and action recognition: a new view on the cortical motor functions. The cognitive neurosciences, 539–552. doi:10.1590/1414-431X20144336.
Rizzolatti, G., Fogassi, L., & Gallese, V. (2001). Neurophysiological mechanisms underlying the understanding and imitation of action. Nature Reviews Neuroscience, 2(9), 661–670. doi:10.1038/35090060.
Rizzolatti, G., Fabbri-Destro, M., & Cattaneo, L. (2009). Mirror neurons and their clinical relevance. Nature Clinical Practice Neurology, 5(1), 24–34. doi:10.1038/ncpneuro0990.
Shimada, S. (2009). Modulation of motor area activity by the outcome for a player during observation of a baseball game. PloS One, 4(11), e8034. doi:10.1371/journal.pone.0008034.
Shmueli, K., van Gelderen, P., de Zwart, J. A., Horovitz, S. G., Fukunaga, M., Jansma, J. M., & Duyn, J. H. (2007). Low-frequency fluctuations in the cardiac rate as a source of variance in the resting-state fMRI BOLD signal. NeuroImage, 38(2), 306–320. doi:10.1016/j.neuroimage.2007.07.037.
Small, S. L., Buccino, G., & Solodkin, A. (2012). The mirror neuron system and treatment of stroke. Developmental Psychobiology, 54(3), 293–310. doi:10.1002/dev.20504.
Smith, S. M., & Nichols, T. E. (2009). Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. NeuroImage, 44(1), 83–98. doi:10.1016/j.neuroimage.2008.03.061.
Sporns, O. (2015). Cerebral cartography and connectomics. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 370, 20140173. doi:10.1098/rstb.2014.0173.
Tettamanti, M., Buccino, G., Saccuman, M. C., Gallese, V., Danna, M., Scifo, P., et al. (2005). Listening to action-related sentences activates fronto-parietal motor circuits. Journal of Cognitive Neuroscience, 17(2), 273–281. doi:10.1162/0898929053124965.
Tranel, D., Kemmerer, D., Adolphs, R., Damasio, H., & Damasio, A. R. (2003). Neural correlates of conceptual knowledge for actions. Cognitive Neuropsychology, 20(3–6), 409–432. doi:10.1080/02643290244000248.
Van Albada, S. J., & Robinson, P. A. (2007). Transformation of arbitrary distributions to the normal distribution with application to EEG test–retest reliability. Journal of Neuroscience Methods, 161(2), 205–211. doi:10.1016/j.jneumeth.2006.11.004.
Wambaugh, J. L. (2002). A summary of treatments for apraxia of speech and review of replicated approaches. Seminars in Speech and Language, 23(4), 293–308. doi:10.1055/s-2002-35802.
Watts, D. J., & Strogatz, S. H. (1998). Collective dynamics of ‘small-world’ networks. Nature, 393, 440–442. doi:10.1038/30918.
Willems, R. M., & Hagoort, P. (2007). Neural evidence for the interplay between language, gesture, and action: a review. Brain and Language, 101(3), 278–289. doi:10.1016/j.bandl.2007.03.004.
Willems, R. M., Toni, I., Hagoort, P., & Casasanto, D. (2010). Neural dissociations between action verb understanding and motor imagery. Journal of Cognitive Neuroscience, 22(10), 2387–2400. doi:10.1162/jocn.2009.21386.
Wood, J. N., & Hauser, M. D. (2008). Action comprehension in non-human primates: motor simulation or inferential reasoning? Trends in Cognitive Sciences, 12(12), 461–465. doi:10.1016/j.tics.2008.08.001.
Zimmermann, P., & Fimm, B. (1994). Tests d’évaluation de l’attention (TEA). Würselen: Psytest.
Zingeser, L. B., & Berndt, R. S. (1990). Retrieval of nouns and verbs in agrammatism and anomia. Brain and Language, 39(1), 14–32. doi:10.1016/0093-934X(90)90002-X.
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Gili, T., Fiori, V., De Pasquale, G. et al. Right sensory-motor functional networks subserve action observation therapy in aphasia. Brain Imaging and Behavior 11, 1397–1411 (2017). https://doi.org/10.1007/s11682-016-9635-1
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DOI: https://doi.org/10.1007/s11682-016-9635-1