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Optimization of parameters for preparation of docetaxel-loaded PLGA nanoparticles by nanoprecipitation method

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Summary

The purpose of this study was to develop docetaxel-poly (lactide-co-glycolide) (PLGA) loaded nanoparticles by using nanoprecipitation method and optimize the relative parameters to obtain nanoparticles with higher encapsulation efficiency and smaller size. The physicochemical characteristics of nanoparticles were studied. The optimized parameters were as follows: the oil phase was mixture of acetone and ethanol, concentration of tocopheryl polyethylene glycol succinate (TPGS) was 0.2%, the ratio of oil phase to water phase was 1:5, and the theoretical drug concentration was 5%. The optimized nanoparticles were spherical with size between 130 and 150 nm. The encapsulation efficiency was (40.83±2.1)%. The in vitro release exhibited biphasic pattern. The results indicate that docetaxel-PLGA nanoparticles were successfully fabricated and may be used as the novel vehicles for docetaxel, which would replace Taxotere® and play great roles in future.

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Authors and Affiliations

  1. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Wei Shi  (施 伟), Zhan-jie Zhang  (张占洁), Yin Yuan  (袁 茵), En-ming Xing  (邢恩明), You Qin  (秦 铀), Zhen-jun Peng  (彭振军) & Kun-yu Yang  (杨坤禹)

  2. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Zhi-ping Zhang  (张志平)

Authors
  1. Wei Shi  (施 伟)
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  2. Zhan-jie Zhang  (张占洁)
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  3. Yin Yuan  (袁 茵)
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  4. En-ming Xing  (邢恩明)
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  5. You Qin  (秦 铀)
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  6. Zhen-jun Peng  (彭振军)
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  7. Zhi-ping Zhang  (张志平)
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  8. Kun-yu Yang  (杨坤禹)
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Corresponding author

Correspondence to Zhen-jun Peng  (彭振军).

Additional information

The authors contributed equally to this work.

This project was supported by National Natural Science Foundation of China (No. H1610 81172121).

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Shi, W., Zhang, Zj., Yuan, Y. et al. Optimization of parameters for preparation of docetaxel-loaded PLGA nanoparticles by nanoprecipitation method. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 33, 754–758 (2013). https://doi.org/10.1007/s11596-013-1192-x

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  • DOI: https://doi.org/10.1007/s11596-013-1192-x

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