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Food Matrix Effects on Nutraceutical Bioavailability: Impact of Protein on Curcumin Bioaccessibility and Transformation in Nanoemulsion Delivery Systems and Excipient Nanoemulsions

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Abstract

Powdered curcumin was either dissolved in the lipid phase of a nanoemulsion delivery system or it was directly mixed with an excipient nanoemulsion. The influence of thermal treatment (30 or 90 °C) and protein addition (caseinate) on the bioaccessibility and transformation of curcumin was then investigated using a simulated gastrointestinal tract (GIT) model: mouth; stomach; small intestine. Curcumin solubility was high in nanoemulsion delivery systems exposed to both thermal treatments because it was already present in the lipid phase. Conversely, curcumin solubility of a powder mixed with an excipient nanoemulsion was appreciably lower when exposed to 30 °C than 90 °C. This effect was attributed to the greater transfer of curcumin to the lipid phase of the excipient nanoemulsions at elevated temperatures. For the heated samples, the bioaccessibility and transformation of curcumin was not greatly affected by original curcumin location or protein addition. However, curcumin bioaccessibility was appreciably higher in the presence of nanoemulsion lipid droplets than in their absence, which was attributed to an increase in the solubilization capacity of the mixed micelle phase. This study provides some useful information for improving the design of functional foods to improve the oral bioavailability profile of lipophilic nutraceuticals.

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Acknowledgments

This material was partly based upon work supported by the USDA, NRI Grants (2011-03539, 2013-03795, 2011-67021, and 2014-67021). We also thank the National Aero and Space Administration (NASA) for partial funding of this research (NNX14AP32G). This project was also partly supported by the National Natural Science Foundation of China (NSFC31428017). This project was also partly funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, under grant numbers 330-130-1435-DSR, 299-130-1435-DSR, 87-130-35-HiCi. The authors, therefore, acknowledge with thanks DSR technical and financial support.

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Authors and Affiliations

  1. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, No. 235 Nanjing East Road, Nanchang, Jiangxi, 330047, China

    Liqiang Zou, Wei Liu & Chengmei Liu

  2. Department of Food Science, University of Massachusetts, Amherst, MA, 01003, USA

    Bingjing Zheng, Ruojie Zhang, Zipei Zhang, Hang Xiao & David Julian McClements

  3. Department of Biochemistry, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah, 21589, Saudi Arabia

    David Julian McClements

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  1. Liqiang Zou
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  2. Bingjing Zheng
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  3. Ruojie Zhang
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  4. Zipei Zhang
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  5. Wei Liu
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  6. Chengmei Liu
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  7. Hang Xiao
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  8. David Julian McClements
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Correspondence to Wei Liu or David Julian McClements.

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Wei Liu and David Julian McClements contributed equally to this manuscript

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Zou, L., Zheng, B., Zhang, R. et al. Food Matrix Effects on Nutraceutical Bioavailability: Impact of Protein on Curcumin Bioaccessibility and Transformation in Nanoemulsion Delivery Systems and Excipient Nanoemulsions. Food Biophysics 11, 142–153 (2016). https://doi.org/10.1007/s11483-016-9425-8

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  • DOI: https://doi.org/10.1007/s11483-016-9425-8

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