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Biomineralized polymer matrix composites for bone tissue repair: a review

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Abstract

Bone defects caused by trauma, infection or bone tumor resection, are highly prevalent. A small number (5%–10%) of these injuries fail to heal due to non-union and require surgical intervention. Currently, the principal treatment options for these defects are autografts, allografts, xenografts or synthetic grafts. The main problems associated with these therapies include pain, infection and donor site morbidity. Bone tissue engineering is a diverse field that focuses on the regeneration of bone by combining cells, scaffolds, growth factors and dynamic forces. There have been many recent studies utilizing biomineralized polymer matrix composites which mimic the natural structure of bone. The principal focus of this review is on recent advances in the synthesis of various types of biomineralized polymer matrix composite. Examples of the biomineralization of naturallyderived and synthetic polymers widely used for bone engineering are also summarized.

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Acknowledgements

This work was supported by the National Key Research and Development Program of China (2017YFC1103500, 2017YFC1103502), the National Natural Science Foundation of China (31525009), Sichuan Innovative Research Team Program for Young Scientists (2016TD0004), Distinguished Young Scholars of Sichuan University (2011SCU04B18), and Sichuan Science and Technology Project (2017GZ0429).

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Authors and Affiliations

  1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China

    Lin Zhong, Ying Qu, Kun Shi, Bingyang Chu, Minyi Lei, Kangkang Huang & Zhiyong Qian

  2. Department of Textile Engineering, College of Light Industry & Textile & Food Engineering, Sichuan University, Chengdu, Sichuan, 610065, China

    Yingchun Gu

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  1. Lin Zhong
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  2. Ying Qu
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  3. Kun Shi
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  6. Kangkang Huang
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  7. Yingchun Gu
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Correspondence to Yingchun Gu or Zhiyong Qian.

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Zhong, L., Qu, Y., Shi, K. et al. Biomineralized polymer matrix composites for bone tissue repair: a review. Sci. China Chem. 61, 1553–1567 (2018). https://doi.org/10.1007/s11426-018-9324-0

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