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FeOOH-loaded mesoporous silica nanoparticles as a theranostic platform with pH-responsive MRI contrast enhancement and drug release

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Abstract

The development of stimuli-responsive theranostic platforms is of great demand for efficient cancer treatment because they can enhance diagnostic specificity and sensitivity. In this work, we report a pH-responsive theranostic nanoplatform based on FeOOH clusters loaded mesoporous silica nanoparticles (Fe@MSNs). The as-synthesized Fe@MSNs possess activatable T1 magnetic resonance imaging (MRI) performance that can respond to the acidic microenvironment of solid tumor to turn on T1 singals by releasing paramagnetic Fe3+ ions. The Fe@MSNs are biocompatible without appreciable cytotoxicity. Moreover, the unique mesoporous structure endows the Fe@MSNs with significant advantages to effectively deliver chemotherapeutic drug for inhibiting the growth of solid tumor. We believe that this novel pH-responsive theranostic nanoplatform holds great promise in cancer treatment.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (81501461, 21635002) and the Open Research Fund for Expensive Instrument Testing of Fuzhou University (2017T026, 2017T028).

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Authors and Affiliations

  1. College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, China

    Guoming Huang, Rui Liu, Yuehua Hu, Yuan Qiu & Jingying Li

  2. Key Laboratory for Analytical Science of Food Safety and Biology, Ministry of Education, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China

    Shi-Hua Li, Ying Wu & Huang-Hao Yang

Authors
  1. Guoming Huang
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  2. Rui Liu
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  3. Yuehua Hu
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  4. Shi-Hua Li
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  5. Ying Wu
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  6. Yuan Qiu
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  7. Jingying Li
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  8. Huang-Hao Yang
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Corresponding author

Correspondence to Jingying Li.

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11426_2017_9217_MOESM1_ESM.pdf

FeOOH-Loaded Mesoporous Silica Nanoparticles as A Theranostic Platform with pH-Responsive MRI Contrast Enhancement and Drug Release

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Huang, G., Liu, R., Hu, Y. et al. FeOOH-loaded mesoporous silica nanoparticles as a theranostic platform with pH-responsive MRI contrast enhancement and drug release. Sci. China Chem. 61, 806–811 (2018). https://doi.org/10.1007/s11426-017-9217-4

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