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Biodegradable polymeric nanoparticles based on amphiphilic principle: construction and application in drug delivery

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  • Special Issue Recent Research Progress of Biomedical Polymers
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Abstract

The use of nanotechnology in drug-delivery systems (DDS) is attractive for advanced diagnosis and treatment of cancer diseases. Biodegradable polymeric nanoparticles, for example, have promising applications as advanced drug carriers in cancer treatment. In this review, we discuss the development of drug-delivery systems based on an amphiphilic principle mainly conducted by our group for anti-cancer drug delivery. We first briefly address the synthetic chemistry for amphiphilic biodegradable polymers. In the second part, we summarize progress in the application of self-assembled polymer micelles using amphiphilic biodegradable copolymers as anti-tumor drug carriers.

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  1. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China

    ShiYong Zhang, Yao Wu, Bin He, Kui Luo & ZhongWei Gu

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Zhang, S., Wu, Y., He, B. et al. Biodegradable polymeric nanoparticles based on amphiphilic principle: construction and application in drug delivery. Sci. China Chem. 57, 461–475 (2014). https://doi.org/10.1007/s11426-014-5076-0

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