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Identification of ALV-J associated acutely transforming virus Fu-J carrying complete v-fps oncogene

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Abstract

Transduction of oncogenes by ALVs and generation of acute transforming viruses is common in natural viral infections. In order to understand the molecular basis for the rapid oncogenicity of Fu-J, an acutely transforming avian leukosis virus isolated from fibrosarcomas in crossbreed broilers infected with subgroup J avian leukosis virus (ALV-J) in China, complete genomic structure of Fu-J virus was determined by PCR amplification and compared with those of Fu-J1, Fu-J2, Fu-J3, Fu-J4, and Fu-J5 reported previously. The results showed that the genome of Fu-J was defective, with parts of gag gene replaced by the complete v-fps oncogene and encoded a 137 kDa Gag-fps fusion protein. Sequence analysis revealed that Fu-J and Fu-J1 to Fu-J5 were related quasi-species variants carrying different lengths of v-fps oncogenes generated from recombination between helper virus and c-fps gene. Comparison of virus carrying v-fps oncogene also gave us a glimpse of the molecular characterization and evolution process of the acutely transforming ALV.

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Acknowledgments

The research was supported by the Grant (#31172330) from National Natural Science Foundation of China. The authors would like to thank Enago (www.enago.cn) for the English language review.

Author contributions

Peng Zhao and Zhizhong Cui contributed to the conception of the study; YiXin Wang, Jianliang Li, and Yang Li carried out experiments; Shuang Chang contributed significantly to analysis and manuscript preparation; YiXin Wang and Jianliang Li wrote the manuscript; Lichun Fang and Xiaolong Sun helped perform the analysis with constructive discussions.

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    Authors and Affiliations

    1. College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Daizong Road No. 61, Tai’an, 271018, Shandong, China

      Yixin Wang, Jianliang Li, Yang Li, Lichun Fang, Xiaolong Sun, Shuang Chang, Peng Zhao & Zhizhong Cui

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    1. Yixin Wang
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    Correspondence to Peng Zhao or Zhizhong Cui.

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    Edited by Zhen F. Fu.

    Yixin Wang and Jianliang Li have contributed equally to this work.

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    Wang, Y., Li, J., Li, Y. et al. Identification of ALV-J associated acutely transforming virus Fu-J carrying complete v-fps oncogene. Virus Genes 52, 365–371 (2016). https://doi.org/10.1007/s11262-016-1301-6

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    • DOI: https://doi.org/10.1007/s11262-016-1301-6

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