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Renal senescence in 2008: progress and challenges

  • Nephrology-Review
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Abstract

Kidneys are significantly affected by profound anatomic and functional changes with senescence. These changes lead to decline in glomerular filtration rate, decreased urinary concentrating and diluting ability, diminished urinary acidification, and impaired potassium clearance, to list a few. Such changes make the elderly prone to drug toxicity and serious fluid and electrolyte imbalance. While the entire mystery of aging is far from being clear, the role of oxidative stress, telomere length, Klotho gene expression, and the renin angiotensin system seem to be the key mechanisms involved in aging. Aging, being a complex process, involves an array of intertwined molecular pathways. Simultaneous study of multiple molecular pathways in parallel could provide invaluable information in understanding the clinical course of kidney aging and elucidating mechanisms that play key roles in the aging process. A better understanding of these mechanisms may help to preserve renal function, improve morbidity and mortality, and hopefully reduce healthcare costs for the aging population.

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Authors and Affiliations

  1. Department of Pathology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-9073, USA

    Xin J. Zhou

  2. Division of Nephrology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA

    Xin J. Zhou & Ramesh Saxena

  3. Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China

    Zhihong Liu

  4. Division of Nephrology & Hypertension, Department of Medicine, UC Irvine Medical Center, Orange, CA, USA

    N. D. Vaziri

  5. United States and Canadian Academy of Pathology, Augusta, GA, USA

    Fred G. Silva

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  1. Xin J. Zhou
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  2. Ramesh Saxena
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  3. Zhihong Liu
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  4. N. D. Vaziri
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  5. Fred G. Silva
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Correspondence to Xin J. Zhou or Ramesh Saxena.

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Zhou, X.J., Saxena, R., Liu, Z. et al. Renal senescence in 2008: progress and challenges. Int Urol Nephrol 40, 823–839 (2008). https://doi.org/10.1007/s11255-008-9405-0

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  • DOI: https://doi.org/10.1007/s11255-008-9405-0

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