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Mixed-ligand oxovanadium complexes incorporating Schiff base ligands: synthesis, DNA interactions, and cytotoxicities

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Abstract

Three oxovanadium complexes, namely [VO(NOSAA)(bpy)] (1) (NOSAA = 2-hydroxy-5-nitrosalicylidene anthranilic acid, bpy = 2,2′-bipyridyl), [VO(NOSAA)(4,4′-dimebpy)] (2) (4,4′-dimebpy = 4,4′-dimethyl-2,2′- bipyridyl), and [VO(NOSAA)(phen)] (3) (phen = 1,10-phenanthroline), have been prepared and characterized. The binding modes and strengths of these complexes with calf thymus DNA (CT-DNA) were studied using various techniques. The chemical nuclease activities and photocleavage reactions of the complexes were also tested. All three complexes interact with CT-DNA through intercalative modes, and complex 3 possesses the largest binding affinity. All three complexes can efficiently cleave pBR322 DNA upon irradiation or under physiological conditions in the presence of H2O2, and complex 3 has the best cleaving ability. In vitro experimental results showed that the three complexes are cytotoxic against myeloma (Ag8.653) and gliomas (U251) cell lines and complex 3 again showed the highest efficacy.

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Acknowledgments

We gratefully acknowledge financial support for this work by the Science and technology Research Project of Guangdong Province (No.2012B031800431), P. R. China and the University Student Innovating Program Foundation of Guangdong Province,P. R. China (No. 1057310014).

Conflict of interest

The authors have declared that there is no conflict of interest.

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Authors and Affiliations

  1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China

    Jiazheng Lu & Haiwei Guo

  2. Chinese Materia Medica Department, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China

    Jiawei Guo & Wei Sang

Authors
  1. Jiazheng Lu
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  2. Jiawei Guo
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  3. Wei Sang
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  4. Haiwei Guo
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Correspondence to Jiazheng Lu.

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Lu, J., Guo, J., Sang, W. et al. Mixed-ligand oxovanadium complexes incorporating Schiff base ligands: synthesis, DNA interactions, and cytotoxicities. Transition Met Chem 38, 481–488 (2013). https://doi.org/10.1007/s11243-013-9714-8

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  • DOI: https://doi.org/10.1007/s11243-013-9714-8

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