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Synthesis, characterization, DNA binding properties, and biological activities of a mixed ligand copper(II) complex of ofloxacin

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Abstract

A mixed ligand coordination compound of copper with ofloxacin (oflo) and phenanthroline (phen) has been synthesized and characterized by means of X-ray single crystal diffraction and spectroscopic methods. Structural features of the coordination compound are described. CD and CV studies of the interactions of the title complex with calf thymus DNA (CT-DNA) show that the complex can bind to CT-DNA by intercalation and electrostatic binding modes. Antibacterial activities of the title compound, a Cu–oflo complex reported earlier and free oflo have been studied against different microorganisms. Both copper complexes enhance the antibacterial activities of the quinolone drugs. The inhibitory effect of the three compounds on two cancer cell lines was measured and the results indicate that the title complex has strongest inhibitory effect.

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References

  1. Chan S, Wong WT (1995) Coord Chem Rev 138:219–296

    Article  CAS  Google Scholar 

  2. Afrasiabi Z, Sinn E, Padhye S, Dutta S, Newton C, Anson CE, Powell AK (2003) J Inorg Biochem 95:306–314

    Article  CAS  Google Scholar 

  3. Sigman DS, Graham DR, Aurora VD, Stern AM (1979) J Biol Chem 254:12269–12272

    CAS  Google Scholar 

  4. Mitscher LA (2005) Chem Rev 105:559–592

    Article  CAS  Google Scholar 

  5. Turel I, Leban I, Bukovec N (1994) J Inorg Biochem 56:273–282

    Article  CAS  Google Scholar 

  6. Turel I, Golic L, Ruiz Ramirez OL (1999) Acta Chim Slov 46:203–211

    CAS  Google Scholar 

  7. Aleixandre V, Herrera G, Urios A, Blanco M (1991) Antimicrob Agents Chemother 35:20–23

    CAS  Google Scholar 

  8. Macias B, Villa MV, Rubio I, Castineiras A, Borras J (2001) J Inorg Biochem 84:163–170

    Article  CAS  Google Scholar 

  9. Gameiroa P, Rodriguesb C, Baptistab T, Sousaa I, Castroa B (2007) Int J Pharm 334:129–136

    Article  Google Scholar 

  10. Tselepi-Kalouli E, Katsaros N (1989) J Inorg Biochem 37:271–282

    Article  CAS  Google Scholar 

  11. Sheldrick M (1998) SHELX-97, programs for crystal structure analysis. University of Gottingen, Gottingen, Germany, pp 97–98

    Google Scholar 

  12. Golobic T, Klavzar A, Philar B, Buglyo P, Tolis E, Rehder D, Sepcic K (2003) J Inorg Biochem 95:199–207

    Article  Google Scholar 

  13. Deacon GB, Phillips RJ (1980) Coord Chem Rev 33:227–250

    Article  CAS  Google Scholar 

  14. Dendrinou-Samara C, Tsotsou G, Raptopoulou CP, Kortsaris A, Kyriakidis D, Kessissoglou DP (1998) J Inorg Biochem 71:171–179

    Article  CAS  Google Scholar 

  15. Sorenson JRJ (1989) Prog Med Chem 26:437–586

    Article  CAS  Google Scholar 

  16. Saha DK, Sandbhor U, Shirisha K, Padhye S, Deobagkar D, Ansond CE, Powell AK (2004) Bioorg Med Chem Lett 14:3027–3032

    Article  CAS  Google Scholar 

  17. King DE, Malone R, Lilley SH (2000) Am Fam Physician 61:2741–2748

    CAS  Google Scholar 

  18. Prabhakan B, Lengaiah P, Reddy KL (1990) Polyhedron 9:805–811

    Article  Google Scholar 

  19. Kwaiatkowski M, Kwaiatkowski E, Olechnowicz A, Bandol G (1991) Inorg Chim Acta 182:117–127

    Article  Google Scholar 

  20. Mendoza-Diaz G, Martinez-Aguilera LMR, Perez-Alonso R, Solans X, Moreno-Espanza R (1993) Inorg Chim Acta 211:133–139

    Article  Google Scholar 

  21. Mendoza-Diaz G, Martinez-Auguilera LMR, Moreno-Esparza R, Pannell KH, Cervantes-Lee F (1993) J Inorg Biochem 50:65–78

    Article  CAS  Google Scholar 

  22. Psomas G, Raptopoulou CP, Iordanidis L, Dendrinou-Samara C, Tangoulis V, Kessissoglou DP (2000) Inorg Chem 39:3042–3048

    Article  CAS  Google Scholar 

  23. Dendrinou-Samara C, Psomas G, Raptopoulou CP, Kessissoglou DP (2001) J Inorg Biochem 83:7–16

    Article  CAS  Google Scholar 

  24. Saha DK, Sandbhor U, Shirisha K, Padhye S, Deobagkar D, Anson CE, Powell AK (2004) Med Chem Lett 14:3027–3032

    Article  CAS  Google Scholar 

  25. Song G, He Y, Cai Z (2004) J Fluoresc 14:705–710

    Article  CAS  Google Scholar 

  26. Rodoriguez M, Bard AJ (1990) Anal Chem 62:2658–2662

    Article  Google Scholar 

  27. Millian KM, Mikkelsen SR (1993) Anal Chem 65:2317–2323

    Article  Google Scholar 

  28. Maheswari PU, Palaniandavar MJ (2004) Inorg Biochem 98:219–230

    Article  Google Scholar 

  29. Song YM, Kang JW, Gao JZ, Feng YF (2000) Chin J Inorg Chem 16:53–57

    CAS  Google Scholar 

  30. Krivis AF, Rabb JM (1996) Science 164:1064–1065

    Article  Google Scholar 

  31. Wang GP, Zhu LG, Yu QS (2003) Chin J Inorg Chem 19:179–182

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Chemistry, Nanjing Xiaozhuang University, 3601 Hongjing Road, 211171, Nanjing, People’s Republic of China

    Chang-Yun Chen, Xiao-Feng Wang, Min-Sheng Liu & Yun-Feng Chen

  2. Department of Life Science, Nanjing Xiaozhuang University, 3601 Hongjing Road, 211171, Nanjing, People’s Republic of China

    Quan-Zhan Chen

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  1. Chang-Yun Chen
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  2. Quan-Zhan Chen
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  3. Xiao-Feng Wang
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  4. Min-Sheng Liu
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  5. Yun-Feng Chen
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Correspondence to Chang-Yun Chen or Quan-Zhan Chen.

Additional information

Chang-Yun Chen and Quan-Zhan Chen contributed equally to this work.

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Chen, CY., Chen, QZ., Wang, XF. et al. Synthesis, characterization, DNA binding properties, and biological activities of a mixed ligand copper(II) complex of ofloxacin. Transition Met Chem 34, 757–763 (2009). https://doi.org/10.1007/s11243-009-9259-z

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  • DOI: https://doi.org/10.1007/s11243-009-9259-z

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