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Preparation and Chemical and Biological Studies of the Novel Complex μ-1,4,5-triphenyl-1,3,4-triazole-2-thiolate-bis[dichlorotriethylphosphineplatinum(II)]a

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Abstract

The mesoionic compound, 1,4,5-triazole-2-thiolate, is a versatile ligand, capable of binding metal centres in different ways. The present study shows how it reacts with the bridging platinum(II) complex μ-dichlorobis[(chlorotriethylphosphineplatinum(II)], [Pt2(PEt3)2Cl4], originating a bimetallic complex. Both the sulphur atom and nitrogen 3 behave as basic sites, coordinating different platinum centres. An interesting isomerization process, shown by 31P{1H} n.m.r. spectroscopy, occurs at the S-bonded platinum moiety, resulting in a fluxional behaviour of the complex. It is also shown to target CT-DNA with moderate binding affinity.

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Authors and Affiliations

  1. Departamento de Química,Instituto de Ciências Exatas, Universidade Federal Juiz de Fora, 36036-330, Juiz de Fora, MG, Brazil

    Wagner M. Teles & Flávia C. Machado

  2. Núcleo de Estudos em Química Medicinal, Departamento de Química,Instituto de Ciências Exatas , Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil

    Carlos A. Montanari

  3. Departamento de Química Inorgânica, Instituto de Química, Universidade Federal do Rio de Janeiro, 21945-970, Rio de Janeiro, RJ, Brazil

    Carlos A. L. Filgueiras

  4. Tom Connors Cancer Research Centre, Yorkshire Cancer Research Laboratory Drug Design, University of Bradford, BD7 1DP W, Bradford, Yorkshire, England

    Terence C. Jenkins

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  1. Wagner M. Teles
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  2. Flávia C. Machado
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  3. Carlos A. Montanari
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  4. Carlos A. L. Filgueiras
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  5. Terence C. Jenkins
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Correspondence to Carlos A. L. Filgueiras.

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To the memory of Dr. Wagner M. Teles (1971–2004).

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Teles, W.M., Machado, F.C., Montanari, C.A. et al. Preparation and Chemical and Biological Studies of the Novel Complex μ-1,4,5-triphenyl-1,3,4-triazole-2-thiolate-bis[dichlorotriethylphosphineplatinum(II)]a. Transition Met Chem 30, 733–737 (2005). https://doi.org/10.1007/s11243-005-6260-z

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  • DOI: https://doi.org/10.1007/s11243-005-6260-z

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