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Metalloantitubercular compounds Part 3: Synthesis, crystal structure, spectroscopy, electrochemistry and antimycobacterial activity of the copper(II) ciproploxacin (cfH) complex and its phenanthroline adduct

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Abstract

The X-ray crystal structures of two ciprofloxacin compounds, viz. [Cu(cfH)2(Cl)2] · 2MeOH · 6H2O (2) and [Cu(cfH)(phen)Cl]BF4 · 4H2O (3) are reported. Complex (2) has a distorted octahedral geometry, whereas for the nitrogen adduct (3) a distorted square–pyramidal geometry is seen. Significant enhancement in the antimycobacterial activity of the copper conjugates correlates with their copper redox couples (Cu2+ /Cu+) probably due to its relevance to intracellular accumulations and subsequent role in generating oxidative stress.

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Authors and Affiliations

  1. Department of Chemistry, University of Pune, Pune, 411 007, India

    Dilip Kumar Saha, Sommai Patitungkho & Subhash Padhye

  2. Department of Zoology, University of Pune, Pune, 411 007, India

    Dileep N. Deobagkar & Aarti Ozarkar

  3. National Chemical Laboratory, Pashan, Pune, 411 008, India

    Mohan M. Bhadbhade & Rajesh G. Gonnade

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  1. Dilip Kumar Saha
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  2. Sommai Patitungkho
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  3. Subhash Padhye
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  4. Dileep N. Deobagkar
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  7. Rajesh G. Gonnade
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Saha, D.K., Patitungkho, S., Padhye, S. et al. Metalloantitubercular compounds Part 3: Synthesis, crystal structure, spectroscopy, electrochemistry and antimycobacterial activity of the copper(II) ciproploxacin (cfH) complex and its phenanthroline adduct. Transition Met Chem 30, 334–340 (2005). https://doi.org/10.1007/s11243-004-5861-2

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  • DOI: https://doi.org/10.1007/s11243-004-5861-2

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