Abstract
The catalytic hydrogenation of benzodiazepinones using metal complexes with phosphite and phosphoramidite ligands was carried out for the first time. The mixed-ligand catalytic systems containing a chiral phosphoramidite or phosphite in combination with an achiral phosphine were shown to exhibit a higher enantioselectivity compared to catalysts containing homocombinations of chiral ligands.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1059—1061, June, 2017.
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Lyubimov, S.E., Ozolin, D.V. & Davankov, V.A. Asymmetric Ir-catalyzed hydrogenation of 1,5-benzodiazepinones using mixtures of ligands. Russ Chem Bull 66, 1059–1061 (2017). https://doi.org/10.1007/s11172-017-1853-1
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DOI: https://doi.org/10.1007/s11172-017-1853-1