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Preparation of chitosan nanoparticles by spray drying, and their antibacterial activity

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Abstract

Chitosan nanoparticles were prepared from chitosan of different molecular weight by spray drying. The morphology of the particles was characterized by SEM, and size distribution and zeta potential were determined. The effects of chitosan solution concentration, molecular weight of chitosan, and size of the spray dryer nozzles on average size, size distribution and zeta potential of chitosan nanoparticles were investigated. The effects of chitosan nanoparticles and chitosan nanoparticles–amoxicillin complex on Staphylococcus aureus were also tested. The results showed that the average size of chitosan nanoparticles were in the range 95.5–395 nm and zeta potentials were 39.3–45.7 mV, depending on the concentration and molecular weight of the chitosan. The lower the concentration and molecular weight of the chitosan, the smaller the chitosan nanoparticles and the higher the zeta potential. Testing for antibacterial activity against S. aureus indicated that chitosan nanoparticles strongly inhibited growth of the bacteria; the minimum inhibitory concentration, 20 μg/mL, was lower than those of chitosan solution or amoxicillin. The antibacterial capacity of chitosan nanoparticles also depended on the size, zeta potential, and molecular weight of the chitosan. Complexation of chitosan nanoparticles with amoxicillin improved the antibacterial activity of amoxicillin.

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Acknowledgments

The authors would like to thank the Department of Science and Technology, Ho Chi Minh City, Viet Nam, for supporting this work (217/2013/HĐ-SKHCN). We also express our thanks to Professor Ro-Dong Park, Chonnam National University, South Korea for your gift of chitosan. This work was supported in part by a grant from the National Science Council, Taiwan (NSC 102-2313-B-032-001-MY3 and NSC 102-2621-M-032-005).

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Authors and Affiliations

  1. Institute of Biotechnology and Environment, Tay Nguyen University, 567 Le Duan Str., Buon Ma Thuot, Vietnam

    La Thi Kim Ngan, Nguyen Tan Vui, Tran Minh Đinh & Nguyen Anh Dzung

  2. Faculty of Medicine and Pharmacy, Tay Nguyen University, 567 Le Duan Str., Buon Ma Thuot, Vietnam

    Phung Minh Luong

  3. Department of Science and Technology, 244, Dien Bien Phu Str., District 3, Ho Chi Minh City, Vietnam

    Đinh Minh Hiep

  4. Department of Chemistry, Tamkang University, Taipei, 251, Taiwan

    San-Lang Wang

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  1. La Thi Kim Ngan
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  2. San-Lang Wang
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  3. Đinh Minh Hiep
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  4. Phung Minh Luong
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  5. Nguyen Tan Vui
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Correspondence to San-Lang Wang or Nguyen Anh Dzung.

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Ngan, L.T.K., Wang, SL., Hiep, Đ.M. et al. Preparation of chitosan nanoparticles by spray drying, and their antibacterial activity. Res Chem Intermed 40, 2165–2175 (2014). https://doi.org/10.1007/s11164-014-1594-9

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  • DOI: https://doi.org/10.1007/s11164-014-1594-9

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