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Deep eutectic solvent for multi-component reactions: a highly efficient and reusable acidic catalyst for synthesis of 2,4,5-triaryl-1H-imidazoles

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Abstract

Efficient synthesis of 2,4,5-trisubstituted imidazoles has been achieved by three-component cyclocondensation of benzil or benzoin, an aldehyde, and ammonium acetate by use of an acidic catalyst. The catalyst is a deep eutectic mixture of choline chloride and oxalic acid that is non-toxic and biodegradable. Crucial advantages of this process are high yields, shorter reaction times, easy work-up, purification of products by non-chromatographic methods, and reusability of the catalyst.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, P.O. Box 91775, Mashhad, Iran

    Mehdi Bakavoli, Hossein Eshghi, Mohammad Rahimizadeh, Mohammad Reza Housaindokht, Ali Mohammadi & Hassan Monhemi

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  1. Mehdi Bakavoli
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  2. Hossein Eshghi
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  3. Mohammad Rahimizadeh
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  4. Mohammad Reza Housaindokht
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  5. Ali Mohammadi
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  6. Hassan Monhemi
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Correspondence to Mehdi Bakavoli or Ali Mohammadi.

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Bakavoli, M., Eshghi, H., Rahimizadeh, M. et al. Deep eutectic solvent for multi-component reactions: a highly efficient and reusable acidic catalyst for synthesis of 2,4,5-triaryl-1H-imidazoles. Res Chem Intermed 41, 3497–3505 (2015). https://doi.org/10.1007/s11164-013-1467-7

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  • DOI: https://doi.org/10.1007/s11164-013-1467-7

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