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Rapid three-component synthesis of pyrimidine and pyrimidinone derivatives in the presence of Bi(NO3)3·5H2O as a mild and highly efficient catalyst

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Abstract

Bismuth(III) nitrate pentahydrate is found as a mild and highly efficient catalyst for the rapid synthesis of 4-amino-5-pyrimidine carbonitrile and pyrimidinone derivatives via three-component reaction of aldehydes, N-unsubstituted amidines, and malononitrile or ethyl cyanoacetate under thermal aqueous conditions. The reaction protocol is rapid and simple which is followed by formation of the corresponding pyrimidine and pyrimidinone derivatives in good to excellent yields with high purity.

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Acknowledgment

The authors express appreciation to the Shahid Bahonar University of Kerman Faculty Research Committee Fund for its support of this investigation.

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Authors and Affiliations

  1. Department of Chemistry, Shahid Bahonar University of Kerman, 76169, Kerman, Iran

    Moahboobeh Zahedifar & Hassan Sheibani

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  1. Moahboobeh Zahedifar
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  2. Hassan Sheibani
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Correspondence to Hassan Sheibani.

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Zahedifar, M., Sheibani, H. Rapid three-component synthesis of pyrimidine and pyrimidinone derivatives in the presence of Bi(NO3)3·5H2O as a mild and highly efficient catalyst. Res Chem Intermed 41, 105–111 (2015). https://doi.org/10.1007/s11164-013-1172-6

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  • DOI: https://doi.org/10.1007/s11164-013-1172-6

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