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Clinical features, diagnosis and treatment of Paget’s disease of bone in mainland China: A systematic review

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Abstract

Paget’s disease of bone (PDB) is a metabolic bone disease with distinct geographical and ethnic differences in its pathogenesis. In this study, we aimed to retrospectively analyze the clinical features and the status of diagnosis and treatment of PDB in mainland China to improve the clinician’s understanding of this disease. For this purpose, we conducted a systematic review of 118 articles, including a total of 332 patients with PDB. The results showed that the onset age of PDB in mainland China was 46–60 years. The number of male patients in most age groups was slightly higher than that of female patients, but there was no statistical difference (p > 0.05). The gender ratio (male to female) of PDB in mainland China was significantly different from that in Japan (p < 0.05), but not from that in the USA (p > 0.05). The clinical manifestations of PDB patients in mainland China mainly included ostealgia, bone malformation, hearing loss, and fracture, and bisphosphonate was used as the main treatment drug. These findings were similar to those in Japan, UK, and USA. Total alkaline phosphatase (TALP) level was elevated in about 89.7% of patients, and no correlation between TALP level and ostealgia was observed (p > 0.05). In addition, no difference in TALP level between males and females in each group was observed (p > 0.05).

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Acknowledgements

This work was supported by grants from the National Nature Science Foundation of China [grant numbers 81471091 and 81870622], the Hunan Nature Science Foundation [grant number 2018JJ2574] and Bethune Charitable Foundation, BCF [grant numer G-X-2019-1107-3].

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Author notes

  1. Wang Qinyi and Fu Shanjiang contributed equally to this work.

Authors and Affiliations

  1. Department of Metabolism & Endocrinology, The 2nd Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan, 410011, People’s Republic of China

    Qin-Yi Wang, Shan-Jiang Fu, Na Ding, Shu-Ying Liu, Rong Chen, Zhang-Xin Wen, Sang Fu & Zhi-Feng Sheng

  2. National Clinical Research Center for Metabolic Diseases, The 2nd Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan, 410011, People’s Republic of China

    Qin-Yi Wang, Shan-Jiang Fu, Na Ding, Shu-Ying Liu, Rong Chen, Zhang-Xin Wen, Sang Fu & Zhi-Feng Sheng

  3. Hunan Key Laboratory for Metabolic Bone Diseases, Health Management Center, The 2nd Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan, 410011, People’s Republic of China

    Qin-Yi Wang, Shan-Jiang Fu, Na Ding, Shu-Ying Liu, Rong Chen, Zhang-Xin Wen, Sang Fu & Zhi-Feng Sheng

  4. Department of Metabolism & Endocrinology, Sanya Central Hospital, 1146 Jiefang 4th Road, Sanya, Hainan, 572000, People’s Republic of China

    Shan-Jiang Fu

  5. Department of Metabolism & Endocrinology, Zhuzhou Central Hospital, Central South University, Zhuzhou, Hunan, 412000, People’s Republic of China

    Rong Chen & Zhang-Xin Wen

  6. Health Management Center, Xiangtan Central Hospital, 120 Heping Road, Xiangtan, Hunan, 411100, People’s Republic of China

    Sang Fu

  7. Hospital Infection Control Center, The 2nd Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan, 410011, People’s Republic of China

    Yang-Na Ou

Authors
  1. Qin-Yi Wang
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  2. Shan-Jiang Fu
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  3. Na Ding
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  4. Shu-Ying Liu
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  5. Rong Chen
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  6. Zhang-Xin Wen
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  7. Sang Fu
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  8. Zhi-Feng Sheng
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  9. Yang-Na Ou
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Contributions

The study conception and design were performed by Sheng Zhifeng and Ou Yangna. Material preparation was performed by Fu Shanjiang, Wang Qinyi, Ding Na and Liu Shuying. Data collection and analysis were performed by Wang Qinyi,Fu Shanjiang,Chen Rong,Wen Zhangxin and Fu Sang. The first draft of the manuscript was written by Wang Qinyi and Fu Shanjiang. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Zhi-Feng Sheng.

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Wang, QY., Fu, SJ., Ding, N. et al. Clinical features, diagnosis and treatment of Paget’s disease of bone in mainland China: A systematic review. Rev Endocr Metab Disord 21, 645–655 (2020). https://doi.org/10.1007/s11154-020-09544-x

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