Abstract
High selectivity (82 %) to 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol, a potent anti-Parkinson drug, was achieved in the isomerization of verbenol oxide at the conversion level of 96 % in N,N-dimethylacetamide at 140 °C over a metal modified zeolite, Fe-Beta-300 with SiO2 to Al2O3 ratio of 300. This catalyst exhibits both weak and medium strong Brønsted and Lewis acid sites.
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Acknowledgments
This work is part of the activities at the Åbo Akademi University, Process Chemistry Centre within the Finnish Centre of Excellence Program appointed by the Academy of Finland. The publication was supported by the UniCRE project, funded by the EU Structural Funds and the state budget of the Czech Republic.
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Stekrova, M., Kumar, N., Mäki-Arvela, P. et al. Opening of monoterpene epoxide to a potent anti-Parkinson compound of para-menthane structure over heterogeneous catalysts. Reac Kinet Mech Cat 110, 449–458 (2013). https://doi.org/10.1007/s11144-013-0615-9
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DOI: https://doi.org/10.1007/s11144-013-0615-9