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Peptides in Colorectal Cancer: Current State of Knowledge

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Abstract

Colorectal cancer (CRC) is the second most deadly and the third most commonly diagnosed cancer in the world. CRC treatment is mainly based on surgery, chemotherapy, and even though the probability of complications after surgery is very low, chemo drugs affect the patient’s quality of life. Multiple studies have shown a strong correlation between diet and the onset and progression of CRC. Thus, the consumption of dietary nutraceuticals for its treatment and prevention has been suggested as a promising option. Peptides have increasingly become of interest in human health due to their antioxidant, antihypertensive, and anticancer potential. In recent years, there have been extensive reports on peptides with anti-tumor activity, and some studies suggest that peptides modulate cell proliferation, evasion of cell death, and metastasis in malignant cells. Plant-derived peptides such as soybean, bean, and rice have received main attention. In this review, we show evidence of several mechanisms through which bioactive peptides exert anti-tumor activity over in vitro and in vivo CRC models. We also report the current status of major production techniques, as well as limitations and future perspectives.

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Abbreviations

BBTIs:

Bowman-Birk trypsin inhibitors

CDKs:

Cyclin-dependent kinases

CDK2:

Cyclin-dependent kinase 2

CRC:

Colorectal cancer

GI:

Gastrointestinal

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Thanks to CONACYT for providing a scholarship to Aviles-Gaxiola (597872).

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  1. Centro de Investigación en Alimentación y Desarrollo, A.C. Coordinación Culiacán, Carretera a Eldorado Km 5.5 Col. Campo El Diez, CP 80110, Culiacán, Sinaloa, Mexico

    Sara Avilés-Gaxiola, Josefina León-Felix, Miguel A. Angulo-Escalante & J. Basilio Heredia

  2. Cátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo, A.C. Coordinación Culiacán, Carretera a Eldorado Km 5.5 Col. Campo El Diez, CP 80110, Culiacán, Sinaloa, Mexico

    Erick P. Gutiérrez-Grijalva

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  1. Sara Avilés-Gaxiola
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Avilés-Gaxiola, S., Gutiérrez-Grijalva, E.P., León-Felix, J. et al. Peptides in Colorectal Cancer: Current State of Knowledge. Plant Foods Hum Nutr 75, 467–476 (2020). https://doi.org/10.1007/s11130-020-00856-6

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