Abstract
Recent studies suggest that hormones act through a web of interacting responses rather than through isolated linear pathways. This signal integration architecture may be one mechanism for increasing the specificity of outcomes in different cellular contexts. Several common themes for cross-regulation between pathways can be observed. Here, we propose a classification scheme for different levels of signaling pathway cross-regulation. This scheme is based on which parts of the individual pathways are acting as information conduits between pathways. Examples from the recent plant hormone biology literature are used to illustrate the different modes of interaction.
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Acknowledgements
This work was supported by the University of Washington. CW is a trainee on the Developmental Biology Predoctoral Training Grant T32HD007183 from the National Institute of Child Health and Human Development.
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K. T. Kuppusamy and C. L. Walcher—co-first-authors.
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Kuppusamy, K.T., Walcher, C.L. & Nemhauser, J.L. Cross-regulatory mechanisms in hormone signaling. Plant Mol Biol 69, 375–381 (2009). https://doi.org/10.1007/s11103-008-9389-2
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DOI: https://doi.org/10.1007/s11103-008-9389-2