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Cognitive function in acromegaly: description and brain volumetric correlates

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Abstract

In acromegaly, we reported on increased rates of affective disorders such as dysthymia and depression, as well as structural brain changes. Objective of this study was to determine if cognitive impairments in patients with acromegaly exist and whether such impairments are associated with structural brain alterations defined by magnetic resonance imaging (MRI). In this cross-sectional study, 55 patients with biochemically confirmed acromegaly were enrolled. MRI data were compared with 87 control subjects. Main outcome measures were performance levels in 13 cognitive tests covering the domains of attention, memory and executive function, with performance below the cut-off level of the 16th percentile rated as impaired. In addition, individual global and hippocampal volume changes were defined for each patient in reference to a normative sample. We found that up to 33.3% of the patients were impaired in the attention, up to 24.1% in the memory, and up to 16.7% in the executive function domain. 67.3% of the patients failed to reach the cut-off level in at least one subtest. MRI demonstrated increased global, left and right hippocampal grey matter and white matter, particularly early in the disease course. Rather few positive than expected negative correlations could be established between the hippocampal grey matter gain and cognitive performance. Cognitive dysfunction, particularly attentional deficits, are common in acromegaly, rendering neuropsychological testing essential in the diagnostic work-up.

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Acknowledgments

We thank Anne Wendl for collecting the neuropsychological data, Iris Miedl, Doris Goy-Alsing, and Sylvia Lang for their valuable contribution in helping to process the patient visits and data. We thank Rosa Hemauer, Elke Schreiter and Reinhold Borschke for their support in MRI data acquisition and postprocessing.The authors C. Sievers and G. K. Stalla disclose support by a research grant from Pfizer Pharma GmbH, Karlsruhe, Germany.

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The authors report no conflict of interest.

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Correspondence to Caroline Sievers.

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Caroline Sievers and P. G. Sämann contributed equally.

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Sievers, C., Sämann, P.G., Pfister, H. et al. Cognitive function in acromegaly: description and brain volumetric correlates. Pituitary 15, 350–357 (2012). https://doi.org/10.1007/s11102-011-0326-z

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