Abstract
The review summarizes data on natural compounds including higher carboxylic acids, acetogenins, lembehynes, and insect pheromones containing bis-methylene-interrupted Z-double bonds in the molecules, general approaches to their synthesis, and the biological activities they exhibit. The review is of interest for a wide circle of researchers in the field of organic, medicinal, phyto- and biochemistry, and pharmacology, and pharmacognosy, as it describes the key strategies of stereoselective formation of bis-methylene-interrupted Z-double bonds, known biological activities of these natural compounds, their total synthesis, and occurrence in plants, animals, and microorganisms.
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Acknowledgements
This studies were financially supported by the Russian Science Foundation (Project No. 18-73-10030), Russian Foundation for Basic Research (Projects Nos. 18-29-09068, 19-03-00603, 18-33-20058), and in accordance with the approved plans for research projects at the IPC RAS State Registration Nos. AAAA-A19-119022290007-9, AAAA-A19-119022290008-6 (2019-2021). The structural studies of synthesized compounds were carried out at the “Agidel” Center for Collective Use at the Ufa Federal Research Center of the Russian Academy of Sciences with the financial support of the Russian Ministry of Education and Science (Grant 2019-05-595-000-058).
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D’yakonov, V.A., Dzhemileva, L.U. & Dzhemilev, U.M. Natural compounds with bis-methylene-interrupted Z-double bonds: plant sources, strategies of total synthesis, biological activity, and perspectives. Phytochem Rev 20, 325–342 (2021). https://doi.org/10.1007/s11101-020-09685-6
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DOI: https://doi.org/10.1007/s11101-020-09685-6