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Phytochemicals and their effective role in the treatment of diabetes mellitus: a short review

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Abstract

There is a global increase in the incidence of diabetes mellitus (DM). Hyperglycemia is one of the prevailing conditions which gives rise to various diabetic complications. The major complications include diabetic nephropathy, retinopathy, neuropathy, delayed wound healing, heart attack, peripheral vascular disturbances and diabetic ketoacidosis. Treatment of complications due to DM always poses a challenge to the attending clinician. Alongsideallopathic medicines, DM and its complications were reported to be effectively treated with various natural products. In the present review, we discuss the role of different phytochemicals which were reported to be beneficial in the treatment of hyperglycemic conditions in DM. Most medicinal plants contain micronutrients, amino acids and proteins, mucilages, essential oils, sterols and triterpenoids, saponins, carotenoids, alkaloids, flavonoids, phenolic acids, tannins, bitter principles and coumarins. We discuss the effective role of these phytochemicals with an emphasis on secondary metabolites which mimic the action of insulin, and highlight their importance as future antidiabetic agents.

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Abbreviations

ALT:

Alanine transaminase

AST:

Aspartate transaminase

CAT:

Catalase

DM:

Diabetes mellitus

FBG:

Fasting blood glucose

GLUT:

Glucose transporter

GSH:

Glutathione

MDA:

Malondialdehyde

PPARγ:

Peroxisome proliferator-activated receptor gamma

PTB1B:

Protein tyrosine phosphatase 1B

SOD:

Superoxide dismutase

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Acknowledgement

The authors acknowledge the kind help and support received from Phytochemical Society of Europe (PSE) and Pierre Fabre Research Institute.

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  1. Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000, Bandar Tun Razak, Kuala Lumpur, Malaysia

    Seong Lin Teoh & Srijit Das

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Correspondence to Srijit Das.

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Teoh, S.L., Das, S. Phytochemicals and their effective role in the treatment of diabetes mellitus: a short review. Phytochem Rev 17, 1111–1128 (2018). https://doi.org/10.1007/s11101-018-9575-z

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