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Self-Assembled and Nanostructured siRNA Delivery Systems

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ABSTRACT

A wide range of organic and inorganic materials have been used in the development of nano-scale self-assembling gene delivery systems to improve the therapeutic efficacy of nucleic acid drugs. Small interfering RNA (siRNA) has recently been recognized as a promising and potent nucleic acid medicine for the treatment of incurable genetic disorders including cancer; however, siRNA-based therapeutics suffer from the same delivery problems as conventional nucleic acid drugs such as plasmid DNA and antisense oligonucleotides. Many of the delivery strategies developed for nucleic acid drugs have been applied to siRNA therapeutics, but they have not produced satisfactory in vivo gene silencing efficiencies to warrant clinical trials. This review discusses recent progress in the development of self-assembled and nanostructured delivery systems for efficient siRNA-induced gene silencing and their potential application in clinical settings.

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ACKNOWLEDGMENTS

This study was supported by the Korea Healthcare Technology R&D Project from the Ministry for Health, Welfare & Family Affairs (A085136), Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2010–0022471), National Research Laboratory Basic Science Research Program (2010–0027955), and WCU Program from the Ministry of Education, and Science and Technology, Republic of Korea.

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  1. School of Pharmacy, Sungkyunkwan University, Suwon, 440–746, South Korea

    Ji Hoon Jeong

  2. Department of Biological Sciences Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Daejeon, 305–701, South Korea

    Tae Gwan Park

  3. Severance Integrative Research Institute for Cerebral & Cardiovascular Diseases, Yonsei University Health System, 250 Seongsanno, Seodaemun-gu, Seoul, 120-752, South Korea

    Sun Hwa Kim

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Jeong, J.H., Park, T.G. & Kim, S.H. Self-Assembled and Nanostructured siRNA Delivery Systems. Pharm Res 28, 2072–2085 (2011). https://doi.org/10.1007/s11095-011-0412-y

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