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Designing Dendrimers for Drug Delivery and Imaging: Pharmacokinetic Considerations

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ABSTRACT

Dendrimers have well-organized high branches with a layered architecture providing a series of versatile chemical modification for various purposes. Consequently, this dendrimer nanotechnology explores a new promising class of nanoscale carriers for therapeutic drugs and imaging reagents using passive and active targeting approaches. By controlling dendritic structures, the biological fate of dendrimer/dendrimer-based drugs can be significantly altered based on their intrinsic physicochemical properties, including the hydrophilicity of the unit molecules, particle size, surface charge, and modification. Accordingly, pharmacokinetic aspects play an important role in the design and development of dendrimer systems for successful in vivo application and clinical translation. This review focuses on the recent progress regarding dendritic architectures, structure-related toxicity, and critical factors affecting the pharmacokinetics and biodistribution of dendrimer/dendrimer-based drugs. A better understanding of the basic aspects of dendritic systems and their pharmacokinetics will help to develop a rationale for the design of dendrimers for the controlled delivery of drugs and imaging reagents for therapeutic or diagnostic purposes.

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ACKNOWLEDGMENTS

We wish to express sincere thanks to Dr. Yasuhiko Hashida of the iCeMS, Kyoto University, Kyoto, Japan for graphic assistance in Fig. 1a. We are grateful for financial support from W. Wijagkanalan by the Japan Society for the Promotion of Sciences (JSPS) through a JSPS research fellowship for young scientists.

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Authors and Affiliations

  1. Department of Drug Delivery Research Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan

    Wassana Wijagkanalan, Shigeru Kawakami & Mitsuru Hashida

  2. The Japan Society for the Promotion of Science (JSPS), Chiyoda-ku, Tokyo, 102-8471, Japan

    Wassana Wijagkanalan

  3. Institute of Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto, 606-8501, Japan

    Wassana Wijagkanalan & Mitsuru Hashida

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  1. Wassana Wijagkanalan
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  2. Shigeru Kawakami
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  3. Mitsuru Hashida
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Correspondence to Wassana Wijagkanalan or Mitsuru Hashida.

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Wijagkanalan, W., Kawakami, S. & Hashida, M. Designing Dendrimers for Drug Delivery and Imaging: Pharmacokinetic Considerations. Pharm Res 28, 1500–1519 (2011). https://doi.org/10.1007/s11095-010-0339-8

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