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Magnetothermally-responsive Nanomaterials: Combining Magnetic Nanostructures and Thermally-Sensitive Polymers for Triggered Drug Release

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Abstract

This paper reviews the design and development of magnetothermally-triggered drug delivery systems, whereby magnetic nanoparticles are combined with thermally-activated materials. By combining superparamagnetic nanoparticles with lower critical solution temperature (LCST) polymers, an alternating current (AC) magnetic field can be used to trigger localized heating in vivo, which in turn causes a phase change in the host polymer to allow diffusion and release of drugs. The use of magnetic nanoparticles for biomedical applications is reviewed, as well as the design of thermally-activated polymeric systems. Current research on externally-triggered delivery is highlighted, with a focus on the design and challenges in developing magnetothermally-activated systems.

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Acknowledgments

Dr. Brazel acknowledges the J. William Fulbright Commission for supporting his sabbatical in the United Kingdom. The University of Alabama’s Alton Scott Memorial Fund supported research in the Magnetic Biomaterials research working group. Discussions with David Nikles, Hitesh Bagaria and Dong-Hyun Kim, collaborators at UA, have also been particularly helpful in developing the manuscript.

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  1. Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, Alabama, 35487-0203, USA

    Christopher S. Brazel

  2. Institute for Science and Technology in Medicine, Keele University, Stoke-on-Trent, Staffordshire, ST4 7QB, UK

    Christopher S. Brazel

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Brazel, C.S. Magnetothermally-responsive Nanomaterials: Combining Magnetic Nanostructures and Thermally-Sensitive Polymers for Triggered Drug Release. Pharm Res 26, 644–656 (2009). https://doi.org/10.1007/s11095-008-9773-2

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