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Spray-drying Nanocapsules in Presence of Colloidal Silica as Drying Auxiliary Agent: Formulation and Process Variables Optimization Using Experimental Designs

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Purpose

Spray-drying process was used for the development of dried polymeric nanocapsules. The purpose of this research was to investigate the effects of formulation and process variables on the resulting powder characteristics in order to optimize them.

Materials and Methods

Experimental designs were used in order to estimate the influence of formulation parameters (nanocapsules and silica concentrations) and process variables (inlet temperature, spray-flow air, feed flow rate and drying air flow rate) on spray-dried nanocapsules when using silica as drying auxiliary agent. The interactions among the formulation parameters and process variables were also studied. Responses analyzed for computing these effects and interactions were outlet temperature, moisture content, operation yield, particles size, and particulate density. Additional qualitative responses (particles morphology, powder behavior) were also considered.

Results

Nanocapsules and silica concentrations were the main factors influencing the yield, particulate density and particle size. In addition, they were concerned for the only significant interactions occurring among two different variables. None of the studied variables had major effect on the moisture content while the interaction between nanocapsules and silica in the feed was of first interest and determinant for both the qualitative and quantitative responses. The particles morphology depended on the feed formulation but was unaffected by the process conditions.

Conclusion

This study demonstrated that drying nanocapsules using silica as auxiliary agent by spray drying process enables the obtaining of dried micronic particle size. The optimization of the process and the formulation variables resulted in a considerable improvement of product yield while minimizing the moisture content.

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Authors and Affiliations

  1. Laboratoire d’Automatique et de Génie des Procédés (LAGEP), UMR 5007 CNRS-UCB Lyon 1, ISPB-UCB Lyon 1, 43 Boulevard du 11 Novembre 1918,, 69622, Villeurbanne cedex, France

    Patrice Tewa-Tagne, Ghania Degobert, Stéphanie Briançon & Hatem Fessi

  2. Laboratoire des Sciences Analytiques (LSA) UMR 5180, CNRS-UCB Lyon 1, 43 Boulevard du 11 Novembre 1918,, 69622, Villeurbanne cedex, France

    Claire Bordes, Jean-Yves Gauvrit &  Pierre Lanteri

Authors
  1. Patrice Tewa-Tagne
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  2. Ghania Degobert
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  3. Stéphanie Briançon
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  4. Claire Bordes
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  7. Hatem Fessi
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Correspondence to Ghania Degobert.

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Tewa-Tagne, P., Degobert, G., Briançon, S. et al. Spray-drying Nanocapsules in Presence of Colloidal Silica as Drying Auxiliary Agent: Formulation and Process Variables Optimization Using Experimental Designs. Pharm Res 24, 650–661 (2007). https://doi.org/10.1007/s11095-006-9182-3

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