Skip to main content
Log in

Phytochemical Composition, Antioxidant and Antibacterial Activities of Crude Extracts from the Species Euphorbia Atlantica Coss.

  • MEDICINAL PLANTS
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

A phytochemical study of crude extracts obtained from Euphorbia atlantica Coss. led to the isolation and structure identification of ten known compounds by spectroscopic analysis including 1D and 2D NMR techniques (1H, 13C, DEPT, COSY, HSQC, HMBC and NOESY), mass spectrometry (ESI-MS), measurements of optical rotation [α]D, and by comparison with the literature data. The total phenolic content was estimated and the antioxidant activities of the petroleum ether and ethyl acetate extracts were evaluated using seven different methods, namely scavenging of the free radicals (ABTS and DPPH), ferric reducing antioxidant power (FRAP), total antioxidant capacity by phosphomolybdate assay (PPM), cupric reducing antioxidant capacity (CUPRAC), and metal chelate and ferrous ion chelating activities. The antibacterial activity of extracts was estimated by the agar disk diffusion assay against four bacterial strains including Staphylococcus albus, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 35218 and Enterobacter sp.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.

Similar content being viewed by others

References

  1. R. Govaerts, D. G. Fordin and A. Radcliffe-Smith, World checklist and bibliography of Euphorbiaceae (and Pandaceae), Vol. 4, The Royal Botanic Gardens, Kew (2000).

    Google Scholar 

  2. P. Quezel and S. Santa, Nouvelle flore de l’Algérie et des régions désertiques méridionales [New flora of Algeria and the southern desert regions], Vol. 1 – 2, CNRS: Paris (1963).

  3. H. Haba, C. Lavaud, H. Harkat, et al., Phytochemistry, 68, 1255 – 1260 (2007).

    Article  CAS  Google Scholar 

  4. H. Haba, C. Lavaud, A. A. Magid, and M. Benkhaled, J. Nat. Prod., 72, 1258 – 1264 (2009).

    CAS  Google Scholar 

  5. H. Haba, L. Marcourt, M. Benkhaled, et al., Nat. Prod. Commun., 8, 1519 – 1522 (2013).

    CAS  PubMed  Google Scholar 

  6. S. Aichour, H. Haba, M. Benkhaled, et al., Phytochem. Lett., 10, 198 – 203 (2014).

    Article  CAS  Google Scholar 

  7. I. Benabdelaziz, S. Gómez-Ruiz, M. Benkhaled, et al., Fitoterapia, 127, 271 – 278 (2018).

    Article  CAS  Google Scholar 

  8. B. Gunda, Ethnological Institute of the University, Debrecen,Hungary and University of California: Special Publications (1966), pp. 1 – 33.

  9. H. B. Li, K. W. Cheng, C. C. Wong, et al., Food Chem., 102., 771 – 776 (2007).

    Article  CAS  Google Scholar 

  10. R. Re, N. Pellegrini, A. Proteggente, et al., Free Radic. Biol. Med., 26.,1231 – 1237 (1999).

    Article  CAS  Google Scholar 

  11. M. Oyaizu, Jpn. J. Nutr., 44, 307 – 315 (1986).

    Article  CAS  Google Scholar 

  12. P. Prieto, M. Pineda, and M. Aguilar, Biochemistry, 269., 337 – 341 (1999).

    CAS  Google Scholar 

  13. R. Apak, K. Güçlü, M. Özyürek, et al., J. Agric. Food Chem., 52, 7970 – 7981 (2004).

    Article  CAS  Google Scholar 

  14. K. Le, F. Chiu, and K. Ng, Food Chem., 105, 353 – 63 (2007).

    Article  CAS  Google Scholar 

  15. E. A. Decker and B. Welch, J. Agric. Food Chem., 38, 674 – 677 (1990).

    Article  CAS  Google Scholar 

  16. M. S. Blois. Nature, 181, 1199 – 1200 (1958).

    Article  CAS  Google Scholar 

  17. H. Falleh, R. Ksouri, K. Chaieb, et al., Compt. Rend. Biol., 331, 372 – 379.

  18. S. Öksüz, R. R. Gil, H. Chai, et al., Planta Med., 60, 594 – 596 (1994).

    Article  Google Scholar 

  19. P. T. De, J. G. Urones, I. S. Marcos, et al., Phytochemistry, 26, 1767 – 1776 (1987).

    Article  Google Scholar 

  20. M. J. U. Ferreira and J. R. Ascenso, Phytochemistry, 51, 439 – 444 (1999).

    Article  CAS  Google Scholar 

  21. P. Riehle, M. Vollmer, and S. Rohn, Food Res. Int., 53, 891 – 899 (2013).

    Article  CAS  Google Scholar 

  22. J. L. Donovan, D. L. Luthria, P. Stremple, et al., J. Chromatogr. B: Biomed. Sci. Appl., 726, 277 – 283 (1999).

    Article  CAS  Google Scholar 

  23. F. A. Lahlou, F. Hmimid, M. Loutfi, et al., Int. J. Pharm. Pharm. Sci., 6, 357 – 360 (2014).

    Google Scholar 

  24. R. Murillo and J. Jakupovic, Ing. Cienc. Quim., 18, 57 – 60 (1998).

    CAS  Google Scholar 

  25. T. O. Idowu, A. O. Ogundaini, A. O. Salau, et al., Phytochemistry, 71, 2092 – 2098 (2010).

    Article  CAS  Google Scholar 

  26. F. L. Hsu, W. J. Huang, T. H. Wu, et al., Int. J. Mol. Sci., 13, 6073 – 6088 (2012).

    Article  CAS  Google Scholar 

  27. F. Medini, H. Fellah, R. Ksouri, et al., J. Taibah Univ. Sci., 8, 216 – 224 (2014).

    Article  Google Scholar 

  28. M. Wang, J. Li, M. Rangarajan, et al., J. Agric. Food Chem., 46, 4869 – 4873 (1998).

    Article  CAS  Google Scholar 

  29. E. A. Shalaby and S. M., Ind. J. Geo-Marine Sci., 42, 556 – 564 (2013).

  30. K. K. Koukoura, K. D. Soklou, T. Tchacondo, et al., J. Rech. Sci. Univ. Lomé (Togo), 19, 447 – 459 (2017).

    Google Scholar 

  31. R. A. Teeli, S. A. Ganie, M. S. Dar, et al., Res. J. Pharm. Technol., 11, 199 – 202. (2018).

    Article  Google Scholar 

  32. T. S. Wilson, and R. D. Stuart, Can. Med. Assoc. J., 93, 8 (1965).

    CAS  PubMed  PubMed Central  Google Scholar 

  33. S. Garcia, B. Wade, C. Bauer, et al., Water Environ. Res., 79, 2387 – 2395 (2007).

    Article  CAS  Google Scholar 

  34. L. Furlaneto-Maia, K. R. Rocha, F. C. Henrique, et al., J. Adv. Microbiol., 4, 175 (2014).

    Article  Google Scholar 

  35. X. Y. Wang, G. H. Tang, C. M. Yuan, et al., Fitoterapia, 1, 64 – 68 (2013).

    Google Scholar 

  36. L. De León, M. R. López, and L. Moujir, Microbiol. Res., 165, 617 – 626 (2010).

    Article  Google Scholar 

  37. A. Kurek, P. Nadkowska, S. Pliszka, et al., Phytomedicine, 19, 515 – 519 (2012).

    Article  CAS  Google Scholar 

  38. P. Y. Chung, P. Navaratnam, and L. Y. Chung, Ann. Clin. Microbiol. Antimicrob., 10, 25 (2011).

    Article  CAS  Google Scholar 

  39. E. WoŸnicka, A. KuŸniar, D. Nowak, et al., Acta Pol. Pharm., 70, 567 – 71 (2013).

    Google Scholar 

  40. J. Echeverría, J. Opazo, L, Mendoza, et al., Molecules, 22, 608 (2017).

    Article  Google Scholar 

  41. K. Ulanowska, A. Tkaczyk, G. Konopa, et al., Arch. Microbiol., 184, 271 – 278 (2006).

    Article  CAS  Google Scholar 

  42. Y. Xie, W. Yang, F. Tang, et al., Curr. Med. Chem., 22, 132 – 149 (2015).

    Article  CAS  Google Scholar 

  43. T. T. Cushnie, and A. J. Lamb, J. Ethnopharmacol., 101, 243 – 248 (2005).

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors wish to express thanks to the Algerian Ministry of Higher Education and Scientific Research for PRFU Project (B00L01UN050120180001) and the Ministerio de Economía and Competitividad (grant no. CTQ2015-66164-R) for financial support. We would also like to thank Centro de Apoyo Tecnológico Universidad Rey Juan Carlos of Móstoles (Madrid) Spain for providing research facilities and technical support.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hamada Haba.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mouffouk, S., Gómez-Ruiz, S., Benkhaled, M. et al. Phytochemical Composition, Antioxidant and Antibacterial Activities of Crude Extracts from the Species Euphorbia Atlantica Coss.. Pharm Chem J 53, 831–837 (2019). https://doi.org/10.1007/s11094-019-02086-w

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-019-02086-w

Keywords

Navigation