Total flavonoids from Vexibia alopecuroides administered for two weeks to rats with alloxan diabetes lowered the blood glucose level and increased the lactic-pyruvic acid redox potential and liver glycogen level. Lipid metabolism, the antioxidant protection system, and peroxidation processes showed a distinct tendency to normalize in vivo through the influence of the total flavonoids. In this respect, total flavonoids from V. alopecuroides were as effective in the conducted experiments as the known anti-diabetes agent diabeton.
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References
V. A. Baraboi, Plant Phenols and Human Health [in Russian], Nauka, Moscow (1984).
V. N. Syrov, A. A. Batyrbekov, and G. Kh. Kilicheva, Immunomodulating Properties of Flavonoids from the Flora of Central Asia [in Russian], Tashkent (2011).
R. E. Dzhafarova, G. Sh. Garaev, and Z. S. Dzhafarkulieva, Prakt. Fitoter., 2, 5 – 12 (2011).
Yu. N. Nuraliev and G. A. Avezov, Eksp. Klin. Farmakol., 55(1), 42 – 44 (1992).
M. D. Mashkovskii, Drugs [in Russian], RIA Novaya Volna, Moscow (2008), p. 561.
V. N. Syrov, M. P. Yuldashev, M. I. Mamutova, et al., Khim.-farm. Zh., 35(1), 29 – 32 (2001); Pharm. Chem. J., 35(1), 30 – 34 (2001).
A. T. Karakashov and E. Vichev, Micromethods in Clinical Laboratory [in Russian], Med. i Fizkul’tura, Sofiya (1968).
L. L. Abell, B. B. Levy, B. B. Brodie, and F. E. Lendall, J. Biol. Chem., 195, 357 – 366 (1952).
B. P. Neri and C. S. Frings, Clin. Chem., 19(10), 1201 – 1202 (1973).
V. N. Titov, E. D. Brener, N. G. Khaltaev, et al., Lab. Delo, 1, 36 – 41 (1979).
W. C. Dumcombe, Biochem. J., 188(1), 7 – 10 (1963).
V. G. Kolb and V. S. Kamyshnikov, Clinical Biochemistry [in Russian], Belarus, Minsk (1976), pp. 171 – 174.
V. N. Orekhovich (ed.), Modern Methods in Biochemistry [in Russian], Meditsina, Moscow (1977), pp. 63 – 64, 66 – 68.
M. A. Korolyuk, L. I. Ivanova, I. G. Maiorova, et al., Lab. Delo, 1, 16 – 19 (1988).
E. E. Dubinina, L. A. Sal’nikova, and L. F. Efimova, Lab. Delo, 10, 30 – 33 (1983).
C. C. Hedrick, S. R. Thorpe, M.-X. Fu, et al., Diabetologia, 43(3), 312 – 320 (2000).
S. Lo, J. C. Russell, and A. W. Taylor, J. Appl. Physiol., 28(2), 234 – 236 (1970).
V. S. Kamyshnikov, Handbook of Clinical-Biochemical Research and Laboratory Diagnostics [in Russian], MEDpress-inform, Moscow (2009), pp. 469 – 471.
M. L. Belen’kii, Elements of Quantitative Assessment of the Pharmacological Effect [in Russian], Medgiz, Leningrad (1963).
M. E. Raiskina (ed.), Methods for in vivo Studies of Cardiac Metabolism [in Russian], Meditsina, Moscow (1970).
N. I. Gorbenko, V. V. Poltorak, A. I. Gladkikh, and O. V. Ivanova, Eksp. Klin. Farmakol., 66(4), 39 – 42 (2009).
M. I. Balabolkin, Diabetology [in Russian], Meditsina, Moscow (2000).
M. I. Balabolkin and E. M. Klebanova, Probl. Endokrinol., 46(6), 29 – 34 (2000).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 12, pp. 38 – 41, December, 2015.
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Yuldasheva, N.K., Égamova, F.R., Ismailova, G.I. et al. Effect of Total Flavonoids from Vexibia alopecuroides on the Course of Experimental Diabetes in Rats. Pharm Chem J 49, 834–837 (2016). https://doi.org/10.1007/s11094-016-1382-5
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DOI: https://doi.org/10.1007/s11094-016-1382-5