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Synthesis of 1,2,4-oxadiazoles (a review)

  • Drug Synthesis Methods and Manufacturing Technology
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Abstract

Methods used for the synthesis of 3,5-substituted 1,2,4-oxadiazoles are reviewed. The syntheses are based mostly on the use of primary amidoximes and acylating agents as the initial reactants. The pathway to another large group of 1,2,4-oxadiazoles proceeding from a broad spectrum of reactants is via their reactions of 1,3-dipolar cycloaddition, in particular, with primary amidoximes.

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Authors and Affiliations

  1. Bekturov Institute of Chemical Sciences, Ministry of Education and Science of the Republic of Kazakhstan, Almaty, Kazakhstan

    L. A. Kayukova

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  1. L. A. Kayukova
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__________

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 10, pp. 32–40, October, 2005.

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Kayukova, L.A. Synthesis of 1,2,4-oxadiazoles (a review). Pharm Chem J 39, 539–547 (2005). https://doi.org/10.1007/s11094-006-0017-7

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  • DOI: https://doi.org/10.1007/s11094-006-0017-7

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