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Molecular profiles for insular low-grade gliomas with putamen involvement

  • Clinical Study
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Background

The newly proposed putamen classification system shows good prognostic value in patients with insular LGGs, yet no study towards the molecular profiles of putamen involved LGGs has been proposed.

Methods

Clinical information and imaging data of patients diagnosed with insular low-grade gliomas were collected retrospectively. Genetic information of the 34 tumors was assessed using RNA-sequencing. Gene set enrichment analysis was further performed to identify the genes showing differential expression between putamen-involved tumors and putamen non-involved tumors. The level of Ki-67 expression was also evaluated.

Results

There were 843 genes identified to be differentially expressed between putamen-involved and non-involved gliomas. Specifically, Gene set enrichment analysis discovered 13 Kyoto Encyclopedia of Genes and Genomes pathways and 37 Gene Ontology Biological Process term were upregulated in putamen-involved low-grade glioma cells. The enriched GO sets with the highest gene counts included cell cycle (42 genes), mitotic cell cycle (24 genes), and cell division (19 genes). Furthermore, high expression of Ki-67 was associated with putamen involvement in insular gliomas.

Conclusions

There is clear genetic variation between putamen-involved and non-involved insular low-grade gliomas. The differential expression of genes related to the processes of cell proliferation, cell migration, or DNA repair may lead to putamen involvement. The findings suggest that among the two subtypes, putamen-involved insular low-grade gliomas have higher malignancy, and the clinical treatment towards the putamen-involved insular low-grade gliomas should be more active.

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Funding

This work was supported by National Basic Research Program of China (No. 2015CB755500), National Natural Science Foundation of China (No. 81601452), Beijing Natural Science Foundation (No. 7174295) and Key science and technology research project of the Hebei provincial health and Family Planning Commission (No. 20171258).

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Author notes

  1. Chunyao Zhou and Yongheng Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantanxili, Beijing, China

    Chunyao Zhou, Xing Liu, Yuchao Liang, Ziwen Fan, Tao Jiang, Yinyan Wang & Lei Wang

  2. Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

    Yongheng Wang, Xing Liu, Tao Jiang, Yinyan Wang & Lei Wang

  3. Department of Neurosurgery, Qinhuangdao First Hospital, Hebei, China

    Yongheng Wang

  4. Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China

    Tao Jiang

Authors
  1. Chunyao Zhou
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  2. Yongheng Wang
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  3. Xing Liu
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  4. Yuchao Liang
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  5. Ziwen Fan
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  6. Tao Jiang
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  7. Yinyan Wang
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  8. Lei Wang
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Corresponding authors

Correspondence to Yinyan Wang or Lei Wang.

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Conflict of interest

We report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

Ethical approval

This retrospective study was approved by the institutional review board of Beijing Tiantan hospital, written consent was obtained from all of our enrolled patients.

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Cite this article

Zhou, C., Wang, Y., Liu, X. et al. Molecular profiles for insular low-grade gliomas with putamen involvement. J Neurooncol 138, 659–666 (2018). https://doi.org/10.1007/s11060-018-2837-1

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  • DOI: https://doi.org/10.1007/s11060-018-2837-1

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