Skip to main content
SpringerLink
Log in

The diagnostic value of preoperative inflammatory markers in craniopharyngioma: a multicenter cohort study

  • Clinical Study
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

To compare the different levels of preoperative inflammatory markers in peripheral blood samples between craniopharyngioma (CP) and other sellar region tumors so as to explore their differential diagnostic value. The level of white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet, albumin, neutrophil lymphocyte ratio (NLR), derived NLR (dNLR), platelet lymphocyte ratio (PLR), monocyte lymphocyte ratio (MLR) and prognostic nutritional index (PNI) were compared between the CP and other sellar region tumors. A receiver operating characteristics (ROC) curve analysis was performed to evaluate the diagnostic significance of the peripheral blood inflammatory markers and their paired combinations for CP including its pathological types. Patients with CP had higher levels of pre-operative WBC, lymphocyte and PNI. The papillary craniopharyngioma (PCP) group had higher neutrophil count and NLR than the adamantinomatous craniopharyngioma (ACP) and healthy control groups whereas the ACP group had higher platelet count and PNI than the PCP and healthy control groups. There were not any significant differences in preoperative inflammatory markers between the primary and recurrent CP groups. The AUC values of WBC, neutrophil, NLR + PLR and dNLR + PLR in PCP were all higher than 0.7. Inflammation seems to be closely correlated with CP’s development. The preoperative inflammatory markers including WBC, neutrophil, NLR + PLR and dNLR + PLR may differentially diagnose PCP, pituitary tumor (PT) and Rathke cleft cyst (RCC). In addition, some statistical results in this study indirectly proved previous experimental conclusions and strictly matched CP’s biological features.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

Abbreviations

CP:

Craniopharyngioma

ACP:

Adamantinomatous craniopharyngioma

PCP:

Papillary craniopharyngioma

PT:

Pituitary tumor

RCC:

Rathke cleft cyst

GBM:

Glioblastoma multiforme

CT:

Computer tomography

MRI:

Magnetic resonance imaging

WBC:

White blood cell

NLR:

Neutrophil lymphocyte ratio

dNLR:

Derived neutrophil lymphocyte ratio

PLR:

Platelet lymphocyte ratio

MLR:

Monocyte lymphocyte ratio

PNI:

Prognostic nutritional index

AUC:

Area under curve

ROC:

Receiver operating characteristic curve

CI:

Confidence interval

References

  1. Larkin SJ, Ansorge O (2013) Pathology and pathogenesis of craniopharyngiomas. Pituitary 16:9–17

    Article  PubMed  Google Scholar 

  2. Martinez-Barbera JP, Buslei R (2015) Adamantinomatous craniopharyngioma: pathology, molecular genetics and mouse models. J Pediatr Endocrinol Metab 28:7–17

    Article  CAS  PubMed  Google Scholar 

  3. Prabhu VC, Brown HG (2005) The pathogenesis of craniopharyngiomas. Childs Nerv Syst 21:622–627

    Article  PubMed  Google Scholar 

  4. Zada G, Lin N, Ojerholm E, Ramkissoon S, Laws ER (2010) Craniopharyngioma and other cystic epithelial lesions of the sellar region: a review of clinical, imaging, and histopathological relationships. Neurosurg Focus 28:E4

    Article  PubMed  Google Scholar 

  5. Mori M, Takeshima H, Kuratsu J (2004) Expression of interleukin-6 in human craniopharyngiomas: a possible inducer of tumor-associated inflammation. Int J Mol Med 14:505–509

    CAS  PubMed  Google Scholar 

  6. Pettorini BL, Inzitari R, Massimi L, Tamburrini G, Caldarelli M, Fanali C, Cabras T, Messana I, Castagnola M, Di Rocco C (2010) The role of inflammation in the genesis of the cystic component of craniopharyngiomas. Childs Nerv Syst 26:1779–1784

    Article  PubMed  Google Scholar 

  7. Wolfe SQ, Heros RC (2010) A Rathke cleft cyst to craniopharyngioma: is there a spectrum?. J Neurosurg 112: 1322–1323 (discussion 1323)

    Article  PubMed  Google Scholar 

  8. Kros JM, Mustafa DM, Dekker LJ, Sillevis SP, Luider TM, Zheng PP (2015) Circulating glioma biomarkers. Neuro Oncol 17:343–360

    Article  CAS  PubMed  Google Scholar 

  9. Yang C, Wang C, Chen X, Chen S, Zhang Y, Zhi F, Wang J, Li L, Zhou X, Li N, Pan H, Zhang J, Zen K, Zhang CY, Zhang C (2013) Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas. Int J Cancer 132:116–127

    Article  CAS  PubMed  Google Scholar 

  10. Liu Y, Wang CH, Li DL, Zhang SC, Peng YP, Peng JX, Song Y, Qi ST, Pan J (2016) TREM-1 expression in craniopharyngioma and Rathke’s cleft cyst: its possible implication for controversial pathology. Oncotarget 7:50564–50574

    PubMed  PubMed Central  Google Scholar 

  11. Nie J, Huang GL, Deng SZ, Bao Y, Liu YW, Feng ZP, Wang CH, Chen M, Qi ST, Pan J (2017) The purine receptor P2 × 7R regulates the release of pro-inflammatory cytokines in human craniopharyngioma. Endocr Relat Cancer 24:287–296

    Article  PubMed  PubMed Central  Google Scholar 

  12. Singh S, Sadanandam A, Nannuru KC, Varney ML, Mayer-Ezell R, Bond R, Singh RK (2009) Small-molecule antagonists for CXCR2 and CXCR1 inhibit human melanoma growth by decreasing tumor cell proliferation, survival, and angiogenesis. Clin Cancer Res 15:2380–2386

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Todd CM, Salter BM, Murphy DM, Watson RM, Howie KJ, Milot J, Sadeh J, Boulet LP, O’Byrne PM, Gauvreau GM (2016) The effects of a CXCR1/CXCR2 antagonist on neutrophil migration in mild atopic asthmatic subjects. Pulm Pharmacol Ther 41:34–39

    Article  CAS  PubMed  Google Scholar 

  14. McMillan DC (2009) Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care 12:223–226

    Article  PubMed  Google Scholar 

  15. Deng Q, He B, Liu X, Yue J, Ying H, Pan Y, Sun H, Chen J, Wang F, Gao T, Zhang L, Wang S (2015) Prognostic value of pre-operative inflammatory response biomarkers in gastric cancer patients and the construction of a predictive model. J Transl Med 13:66

    Article  PubMed  PubMed Central  Google Scholar 

  16. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD (2011) Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 17:47–58

    Article  CAS  PubMed  Google Scholar 

  17. Gu L, Li H, Chen L, Ma X, Li X, Gao Y, Zhang Y, Xie Y, Zhang X (2016) Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis. Oncotarget 7:31926–31942

    PubMed  PubMed Central  Google Scholar 

  18. Raffetti E, Donato F, Castelnuovo F, Ladisa N, Paraninfo G, Di Filippo E, Segala D, Cologni G, Bandera A, Zacchi F, Digiambenedetto S, Di Pietro M, Castelli F, Quiros-Roldan E (2015) The prognostic role of systemic inflammatory markers on HIV-infected patients with non-Hodgkin lymphoma, a multicenter cohort study. J Transl Med 13:89

    Article  PubMed  PubMed Central  Google Scholar 

  19. Andoniadou CL, Gaston-Massuet C, Reddy R, Schneider RP, Blasco MA, Le Tissier P, Jacques TS, Pevny LH, Dattani MT, Martinez-Barbera JP (2012) Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma. Acta Neuropathol 124:259–271

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Gump JM, Donson AM, Birks DK, Amani VM, Rao KK, Griesinger AM, Kleinschmidt-DeMasters BK, Johnston JM, Anderson RC, Rosenfeld A, Handler M, Gore L, Foreman N, Hankinson TC (2015) Identification of targets for rational pharmacological therapy in childhood craniopharyngioma. Acta Neuropathol Commun 3:30

    Article  PubMed  PubMed Central  Google Scholar 

  21. Jia J, Zheng X, Chen Y, Wang L, Lin L, Ye X, Chen Y, Chen D, Dettke M (2015) Stage-dependent changes of preoperative neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in colorectal cancer. Tumour Biol 36:9319–9325

    Article  CAS  PubMed  Google Scholar 

  22. Kilincalp S, Coban S, Akinci H, Hamamci M, Karaahmet F, Coskun Y, Ustun Y, Simsek Z, Erarslan E, Yuksel I (2015) Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as potential biomarkers for early detection and monitoring of colorectal adenocarcinoma. Eur J Cancer Prev 24:328–333

    Article  CAS  PubMed  Google Scholar 

  23. Becht E, Giraldo NA, Germain C, de Reynies A, Laurent-Puig P, Zucman-Rossi J, Dieu-Nosjean MC, Sautes-Fridman C, Fridman WH (2016) Immune contexture, immunoscore, and malignant cell molecular subgroups for prognostic and theranostic classifications of cancers. Adv Immunol 130:95–190

    Article  PubMed  Google Scholar 

  24. Fridman WH, Pages F, Sautes-Fridman C, Galon J (2012) The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 12:298–306

    Article  CAS  PubMed  Google Scholar 

  25. Giraldo NA, Becht E, Pages F, Skliris G, Verkarre V, Vano Y, Mejean A, Saint-Aubert N, Lacroix L, Natario I, Lupo A, Alifano M, Damotte D, Cazes A, Triebel F, Freeman GJ, Dieu-Nosjean MC, Oudard S, Fridman WH, Sautes-Fridman C (2015) Orchestration and prognostic significance of immune checkpoints in the microenvironment of primary and metastatic renal cell cancer. Clin Cancer Res 21:3031–3040

    Article  CAS  PubMed  Google Scholar 

  26. Nakano O, Sato M, Naito Y, Suzuki K, Orikasa S, Aizawa M, Suzuki Y, Shintaku I, Nagura H, Ohtani H (2001) Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity. Cancer Res 61:5132–5136

    CAS  PubMed  Google Scholar 

  27. Thompson ED, Zahurak M, Murphy A, Cornish T, Cuka N, Abdelfatah E, Yang S, Duncan M, Ahuja N, Taube JM, Anders RA, Kelly RJ (2017) Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma. Gut 66:794–801

    Article  PubMed  Google Scholar 

  28. Baecher-Allan C, Anderson DE (2006) Regulatory cells and human cancer. Semin Cancer Biol 16:98–105

    Article  CAS  PubMed  Google Scholar 

  29. Donson AM, Apps J, Griesinger AM, Amani V, Witt DA, Anderson RC, Niazi TN, Grant G, Souweidane M, Johnston JM (2017) Molecular analyses reveal inflammatory mediators in the solid component and cyst fluid of human adamantinomatous craniopharyngioma. J Neuropath Exp Neur:x61

  30. Muller HL (2016) Craniopharyngioma and hypothalamic injury: latest insights into consequent eating disorders and obesity. Curr Opin Endocrinol Diabetes Obes 23:81–89

    Article  PubMed  Google Scholar 

  31. Buergy D, Wenz F, Groden C, Brockmann MA (2012) Tumor-platelet interaction in solid tumors. Int J Cancer 130:2747–2760

    Article  CAS  PubMed  Google Scholar 

  32. Kaser A, Brandacher G, Steurer W, Kaser S, Offner FA, Zoller H, Theurl I, Widder W, Molnar C, Ludwiczek O, Atkins MB, Mier JW, Tilg H (2001) Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis. Blood 98:2720–2725

    Article  CAS  PubMed  Google Scholar 

  33. Bambury RM, Teo MY, Power DG, Yusuf A, Murray S, Battley JE, Drake C, O’Dea P, Bermingham N, Keohane C, Grossman SA, Moylan EJ, O’Reilly S (2013) The association of pre-treatment neutrophil to lymphocyte ratio with overall survival in patients with glioblastoma multiforme. J Neurooncol 114:149–154

    Article  CAS  PubMed  Google Scholar 

  34. Han S, Liu Y, Li Q, Li Z, Hou H, Wu A (2015) Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma. Bmc Cancer 15:617

    Article  PubMed  PubMed Central  Google Scholar 

  35. Szkandera J, Gerger A, Liegl-Atzwanger B, Absenger G, Stotz M, Friesenbichler J, Trajanoski S, Stojakovic T, Eberhard K, Leithner A, Pichler M (2014) The lymphocyte/monocyte ratio predicts poor clinical outcome and improves the predictive accuracy in patients with soft tissue sarcomas. Int J Cancer 135:362–370

    Article  CAS  PubMed  Google Scholar 

  36. Wei J, Gabrusiewicz K, Heimberger A (2013) The controversial role of microglia in malignant gliomas. Clin Dev Immunol 2013 285246

    Article  PubMed  PubMed Central  Google Scholar 

  37. Zhou W, Ke SQ, Huang Z, Flavahan W, Fang X, Paul J, Wu L, Sloan AE, McLendon RE, Li X, Rich JN, Bao S (2015) Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. Nat Cell Biol 17:170–182

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Chen M, Zheng SH, Liu Y, Shi J, Qi ST (2016) Periostin activates pathways involved in epithelial-mesenchymal transition in adamantinomatous craniopharyngioma. J Neurol Sci 360:49–54

    Article  CAS  PubMed  Google Scholar 

  39. Yue X, Lan F, Hu M, Pan Q, Wang Q, Wang J (2016) Downregulation of serum microRNA-205 as a potential diagnostic and prognostic biomarker for human glioma. J Neurosurg 124:122–128

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors would like to thank all the individuals who offered help and advice on this study.

Author information

Author notes

    Authors and Affiliations

    1. Department of Neurosurgery, XinHua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200092, China

      Ming Chen, Min Yang & Shi-ting Li

    2. Department of Neurosurgery, Fujian Provincial Hospital, Fuzhou, Fujian, China

      Shi-hao Zheng

    3. Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

      Zhi-hua Chen

    Authors
    1. Ming Chen
      View author publications

      You can also search for this author in PubMed Google Scholar

    2. Shi-hao Zheng
      View author publications

      You can also search for this author in PubMed Google Scholar

    3. Min Yang
      View author publications

      You can also search for this author in PubMed Google Scholar

    4. Zhi-hua Chen
      View author publications

      You can also search for this author in PubMed Google Scholar

    5. Shi-ting Li
      View author publications

      You can also search for this author in PubMed Google Scholar

    Corresponding author

    Correspondence to Shi-ting Li.

    Ethics declarations

    Disclosure

    The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

    Additional information

    Ming Chen, Shi-hao Zheng and Min Yang contributed equally to this work.

    Electronic supplementary material

    Rights and permissions

    Reprints and permissions

    About this article

    Check for updates. Verify currency and authenticity via CrossMark

    Cite this article

    Chen, M., Zheng, Sh., Yang, M. et al. The diagnostic value of preoperative inflammatory markers in craniopharyngioma: a multicenter cohort study. J Neurooncol 138, 113–122 (2018). https://doi.org/10.1007/s11060-018-2776-x

    Download citation

    • Received:

    • Accepted:

    • Published:

    • Issue Date:

    • DOI: https://doi.org/10.1007/s11060-018-2776-x

    Keywords

    Search

    Navigation