Abstract
To compare the different levels of preoperative inflammatory markers in peripheral blood samples between craniopharyngioma (CP) and other sellar region tumors so as to explore their differential diagnostic value. The level of white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet, albumin, neutrophil lymphocyte ratio (NLR), derived NLR (dNLR), platelet lymphocyte ratio (PLR), monocyte lymphocyte ratio (MLR) and prognostic nutritional index (PNI) were compared between the CP and other sellar region tumors. A receiver operating characteristics (ROC) curve analysis was performed to evaluate the diagnostic significance of the peripheral blood inflammatory markers and their paired combinations for CP including its pathological types. Patients with CP had higher levels of pre-operative WBC, lymphocyte and PNI. The papillary craniopharyngioma (PCP) group had higher neutrophil count and NLR than the adamantinomatous craniopharyngioma (ACP) and healthy control groups whereas the ACP group had higher platelet count and PNI than the PCP and healthy control groups. There were not any significant differences in preoperative inflammatory markers between the primary and recurrent CP groups. The AUC values of WBC, neutrophil, NLR + PLR and dNLR + PLR in PCP were all higher than 0.7. Inflammation seems to be closely correlated with CP’s development. The preoperative inflammatory markers including WBC, neutrophil, NLR + PLR and dNLR + PLR may differentially diagnose PCP, pituitary tumor (PT) and Rathke cleft cyst (RCC). In addition, some statistical results in this study indirectly proved previous experimental conclusions and strictly matched CP’s biological features.
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Abbreviations
- CP:
-
Craniopharyngioma
- ACP:
-
Adamantinomatous craniopharyngioma
- PCP:
-
Papillary craniopharyngioma
- PT:
-
Pituitary tumor
- RCC:
-
Rathke cleft cyst
- GBM:
-
Glioblastoma multiforme
- CT:
-
Computer tomography
- MRI:
-
Magnetic resonance imaging
- WBC:
-
White blood cell
- NLR:
-
Neutrophil lymphocyte ratio
- dNLR:
-
Derived neutrophil lymphocyte ratio
- PLR:
-
Platelet lymphocyte ratio
- MLR:
-
Monocyte lymphocyte ratio
- PNI:
-
Prognostic nutritional index
- AUC:
-
Area under curve
- ROC:
-
Receiver operating characteristic curve
- CI:
-
Confidence interval
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The authors would like to thank all the individuals who offered help and advice on this study.
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The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.
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Ming Chen, Shi-hao Zheng and Min Yang contributed equally to this work.
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Chen, M., Zheng, Sh., Yang, M. et al. The diagnostic value of preoperative inflammatory markers in craniopharyngioma: a multicenter cohort study. J Neurooncol 138, 113–122 (2018). https://doi.org/10.1007/s11060-018-2776-x
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DOI: https://doi.org/10.1007/s11060-018-2776-x