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Genetic Features of Cerebral Stroke

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Recent years have seen an increase in interest in the identification of additional genetic factors for cerebral stroke. A large number of studies have been run with the aim of verifying genetic influences on the risk of developing both ischemic and hemorrhagic stroke. This article discusses the main genes for susceptibility and genetic polymorphisms associated with the development of this disease. An important role in the occurrence of stroke is played by genetic factors controlling the processes of inflammation, blood clotting, lipid metabolism, nitric oxide formation, the functioning of the renin–angiotensin–aldosterone system, and homeostasis. Complex analysis of a number of genes allows patients with the greatest predisposition to developing the disease to be identified with the aims of providing state-of-the-art prophylaxis and reducing the burden of stroke.

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  1. Pirogov Russian National Research Medical University, Russian Ministry of Health, Moscow, Russia

    L. T. Khasanova, L. V. Stakhovskaya & E. A. Koltsova

  2. Federal Center for Cerebrovascular Pathology and Stroke, Russian Ministry of Health, Moscow, Russia

    N. A. Shamalov

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  1. L. T. Khasanova
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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 119, No. 12, Iss. 2, Stroke, pp. 65–72, December, 2019.

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Khasanova, L.T., Stakhovskaya, L.V., Koltsova, E.A. et al. Genetic Features of Cerebral Stroke. Neurosci Behav Physi 50, 992–999 (2020). https://doi.org/10.1007/s11055-020-00997-w

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