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Multifunctional CuS nanocrystals for inhibiting both osteosarcoma proliferation and bacterial infection by photothermal therapy

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Abstract

Photothermal therapy (PTT) has attracted great attention in cancer therapy because of high efficiency and low side effect. The semiconductors have been proved to be ideal photothermal agents in the past years. Herein, we synthesized a novel hexahedron structure of polyvinyl pyrrolidone (PVP) coating CuS nanocrystals (NCs) by a facile hydrothermal method. The synthesized CuS NCs (150 nm for average length of edge and 125 nm for length of width) have good biocompatibility due to their PVP coating and strong absorption in the near infrared region. Moreover, the CuS NCs exhibit high photothermal conversion efficiency as well as good antibacterial effect. Notably, the proliferation of osteosarcoma cancer cells can be efficiently inhibited both in vitro and in vivo by the fatal heat with very low concentration of CuS NCs under the near infrared ray at a power density of 0.5 W/cm2. Therefore, the CuS-PVP NCs have great potential to work as an ideal photothermal and antibacterial agent in clinical applications.

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Authors and Affiliations

  1. Southern Medical University, No. 1023, South Shatai Road, Baiyun District, Guangzhou, Guangdong, 510515, China

    Xiaoming Hu, Yao Lu, Yangqing Lei & Chengcheng Zhang

  2. Department of Orthopedics, Guangzhou General Hospital of Guangzhou Military Command, 111 Liuhua Road, Guangzhou, Guangdong, 510010, China

    Xiaoming Hu, Yao Lu, Yangqing Lei, Chengcheng Zhang, Qingshui Yin & Yu Zhang

  3. Guangdong Key Lab of Orthopedic Technology and Implant, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong, 510010, China

    Lihua Li & Cong Liu

Authors
  1. Xiaoming Hu
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  2. Lihua Li
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  3. Yao Lu
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  4. Cong Liu
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  5. Yangqing Lei
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  6. Chengcheng Zhang
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  7. Qingshui Yin
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  8. Yu Zhang
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Corresponding author

Correspondence to Qingshui Yin.

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Funding Information

We appreciate the financial support from the National Key Research Program of China (Grant No. 2017YFB0702604 and 2016YFB0700803), National Natural Science Foundation of China (Grant Nos. 81501859 and 81601884), Natural Science Foundation of Guangdong Province, China (Grant No. 2015A030312004), and Scientific and Technological Projects of Guangzhou, China (Grant No. 201604020110).

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The authors declare that they have no conflict of interest.

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Hu, X., Li, L., Lu, Y. et al. Multifunctional CuS nanocrystals for inhibiting both osteosarcoma proliferation and bacterial infection by photothermal therapy. J Nanopart Res 19, 295 (2017). https://doi.org/10.1007/s11051-017-3992-6

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