Abstract
Degradation is the long-existing toxic issue of metal-containing inorganic medicine. In this paper, we fully investigated the degradation of dextran-coated KMnF3 nanocube in the in vitro and in vivo surroundings. Different from the general decomposing and ion releasing events, this special agent is resistant to acidic environment, as well as ion exchange. Non-degradability was proved by simulated and real cellular experiments. Moreover, it can be engulfed in the macrophage cells and kept stable in the lysosome. Due to its stability and highly selective phagocytosis, implanted liver cancer can be clearly visualized after administration.
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Acknowledgments
This work is financially supported by the National Natural Science Foundation of China (21361018), the Natural Science Foundation of Jiangxi Province (20151BAB203004), and The China Scholarship Council. The authors acknowledge Jian-qi Li (Shanghai Key Lab of Magnetic Resonance) for helpful discussion and in vivo MRI operation.
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Chen, FY., Gu, ZJ., Zhao, D. et al. Non-degradable contrast agent with selective phagocytosis for cellular and hepatic magnetic resonance imaging. J Nanopart Res 17, 357 (2015). https://doi.org/10.1007/s11051-015-3161-8
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DOI: https://doi.org/10.1007/s11051-015-3161-8