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Biomaterial properties evaluation of poly(vinyl acetate-alt-maleic anhydride)/chitosan nanocapsules

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Abstract

Nanocapsules with diameter around 100 nm based on a natural polymer (chitosan) and a synthetic polymer poly(vinyl acetate-alt-maleic anhydride) [poly(MAVA)] by interfacial condensation method were prepared. The present study proposes a new type of biocompatible nanocapsules based on poly(vinyl acetate-alt-maleic anhydride-chitosan) (MCS) able to become a reliable support for inclusion and release of drugs. The spherical shape of the nanocapsules was evidenced by scanning electron microscopy. Nanocapsules presented a good Norfloxacin loading and release capacity. Haemocompatibility tests have demonstrated that the nanocapsules present a low toxicity and a good compatibility with sanguine medium. The biocompatibility properties of the nanocapsules after their intraperitoneal administration in rats were evidenced by histopathological examination of different organs (brain, liver, kidney, and lung). The results are encouraging and the nanocapsules can be used as controlled drug delivery systems.

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Authors and Affiliations

  1. Faculty of Chemical Engineering and Environmental Protection, Department of Natural and Synthetic Polymers, “Gheorghe Asachi” Technical University of Iasi, Prof.dr. docent Dimitrie Mangeron Avenue, 73, 700050, Iasi, Romania

    Delia Mihaela Raţă, Marcel Popa & Cătălina Anişoara Peptu

  2. Matériaux-Polymères-Interfaces-Environnement Marin (MAPIEM) Laboratory, University of Sud Toulon-Var, Avenue de l’Université, BP 20132, 83957, La Garde Cedex, France

    Jean-François Chailan

  3. Department of Morpho-Functional Sciences, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115, Iasi, Romania

    Carmen Lăcrămioara Zamfir

  4. Faculty of Medical Dentistry, “Apollonia” University of Iasi, Muzicii Street, No. 2, 700511, Iasi, Romania

    Delia Mihaela Raţă

Authors
  1. Delia Mihaela Raţă
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  2. Marcel Popa
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  3. Jean-François Chailan
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  4. Carmen Lăcrămioara Zamfir
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  5. Cătălina Anişoara Peptu
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Correspondence to Cătălina Anişoara Peptu.

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Raţă, D.M., Popa, M., Chailan, JF. et al. Biomaterial properties evaluation of poly(vinyl acetate-alt-maleic anhydride)/chitosan nanocapsules. J Nanopart Res 16, 2569 (2014). https://doi.org/10.1007/s11051-014-2569-x

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  • DOI: https://doi.org/10.1007/s11051-014-2569-x

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