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Biocompatibility of transition metal-substituted cobalt ferrite nanoparticles

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Abstract

Transition metals of copper, zinc, manganese, and nickel were substituted into cobalt ferrite nanoparticles via a sol–gel route using citric acid as a chelating agent. The microstructure and elemental compositions of the nanoparticles were characterized using scanning electron microscopy combined with energy dispersive X-ray spectroscopy. The particle size of the nanoparticles was investigated using particle size analyzer, and the zeta potentials were measured using zeta potential analyzer. The phase components of the synthesized transition metal-substituted cobalt ferrite nanoparticles were studied using Raman spectroscopy. The biocompatibility of the nanoparticles was assessed using osteoblast-like cells. Results indicated that the substitution of transition metals strongly influences the physical, chemical properties, and biocompatibility of the cobalt ferrite nanoparticles.

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Acknowledgments

Dr. Sanpo is the recipient of Swinburne University Postgraduate Research Award (SUPRA). The authors wish to thank the Rajamangala University of Technology Phra Nakhon (RMUTP), Bangkok, Thailand.

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Authors and Affiliations

  1. Faculty of Engineering and Industrial Sciences, Industrial Research Institute Swinburne (IRIS), Swinburne University of Technology, Hawthorn, VIC, 3122, Australia

    Noppakun Sanpo, Christopher C. Berndt, Cuie Wen & James Wang

  2. Division of Industrial Materials Science, Faculty of Science and Technology, Rajamangala University of Technology Phra Nakhon, Bangkok, Thailand

    Jirasak Tharajak

  3. Institute for Frontier Materials, Deakin University, Geelong, VIC, 3217, Australia

    Yuncang Li

  4. Materials Science and Engineering, Stony Brook University, Stony Brook, NY, 11794, USA

    Christopher C. Berndt

Authors
  1. Noppakun Sanpo
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  2. Jirasak Tharajak
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  3. Yuncang Li
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  4. Christopher C. Berndt
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  5. Cuie Wen
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  6. James Wang
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Correspondence to Noppakun Sanpo or Jirasak Tharajak.

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Sanpo, N., Tharajak, J., Li, Y. et al. Biocompatibility of transition metal-substituted cobalt ferrite nanoparticles. J Nanopart Res 16, 2510 (2014). https://doi.org/10.1007/s11051-014-2510-3

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