Abstract
This study was aimed at developing a nanoparticles system for curcumin, a widely used traditional Chinese medicine, but with the disadvantage of poor aqueous solubility. The objective was intended to improve in vitro release characteristics, enhance blood and gastrointestinal stability, increase bioavailability and pharmacological activities. Curcumin nanoparticles system (Cur-NS) was prepared by ionotropic gelation technique. Cur-NS was characterized by particle size, zeta potential, drug entrapment efficiency, drug loading, and physical stability, respectively. Cur-NS presented controlled release properties, and the release properties of Cur from NS were fit non-Fickian mechanism, controlled by the expected diffusional release and the erosion or solubilization from the crosslink layer of polymer carrier. In addition, the pharmacokinetic study in rats revealed a notable improved oral bioavailability of Cur, and the anti-tumor activity in vivo of Cur-NS on tumor growth was investigated. Cur-NS significantly inhibited tumor effect compared with non-vehicle group, thus making it a potential candidate for cancer therapy.
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Acknowledgments
This research was supported in part by grants from the Administration of Traditional Chinese Medicine of Heilongjiang Program (Grant No. ZHY12-Z194), the Natural Science Youth Foundation (Grant No. Sq2012-47), the Heilongjiang education department natural science research (Grant No. 12531667), and financed by the National Undergraduate Training Programs for Innovation and Entrepreneurship (201310222046), and Natural Science Foundation of Heilongjiang Province (Grant No. D201158).
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Sun, W., Zou, Y., Guo, Y. et al. Construction and characterization of curcumin nanoparticles system. J Nanopart Res 16, 2317 (2014). https://doi.org/10.1007/s11051-014-2317-2
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DOI: https://doi.org/10.1007/s11051-014-2317-2