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Mannose-functionalized porous silica-coated magnetic nanoparticles for two-photon imaging or PDT of cancer cells

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Abstract

An original fluorophore engineered for two-photon excitation or a porphyrin derivative were entrapped in the silica shell of magnetic porous silica nanoparticles during the synthesis of the silica moiety without damaging the structure of the organic part. The mild conditions involved allowed obtaining microporous or mesoporous silica magnetic nanoparticles, respectively. Mannose was grafted on the surface of the nanoparticles to target MCF-7 breast cancer cells. The studies of magnetic properties of these hybrid nanoparticles show that they present a blocking temperature at 190 K. The nano-objects designed with the two-photon fluorophore were efficient for two-photon imaging of MCF-7 cancer cells, whereas the nano-objects with the photosensitizer efficiently killed cancer cells. The presence of the mannose moiety was demonstrated to improve both imaging and therapy properties.

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Acknowledgments

GDR “GDR CNRS 3049 Photomed Médicaments photoactivables—Photochimiothérapie,” Association pour la Recherche sur le Cancer” no SFI20101201906 and the non-profit organization Rétinostop is gratefully acknowledged. We gratefully thank Michel Gleizes for technical assistance, Emmanuel Schaub from PIXEL platform (multiphotonic microscopy facilities, University of Rennes 1), Corine Reibel and PAC, ICGM for magnetic measurements. L. L. thanks the UFI (GF/IR/732/07, no 25) for financial support. J.O.D, J.L., M.P., Y. G., L.R. thank CNRS, Université Montpellier 2 for financial support.

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Authors and Affiliations

  1. Institut des Biomolécules Max Mousseron UMR 5247 CNRS, Faculté de Pharmacie, Université Montpellier 1, Université Montpellier 2, 15 Avenue Charles Flahault, 34093, Montpellier Cedex 05, France

    Magali Gary-Bobo, Alain Morère & Marcel Garcia

  2. Institut des Sciences Moléculaires, UMR CNRS 5255, Université Bordeaux, 351 Cours de la Libération, 33405, Talence Cedex, France

    Mireille Blanchard-Desce

  3. Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-UM2-ENSCM-UM1, CC1701 Place Eugène Bataillon, 34095, Montpellier Cedex 05, France

    Marine Perrier, Lenaïc Lartigue, David Brevet, Laurence Raehm, Yannick Guari, Joulia Larionova & Jean-Olivier Durand

  4. UMR 176 CNRS, Institut Curie, Université Paris-Sud, Bât 110-112, 91405, Orsay, France

    Philippe Maillard

  5. Section de Recherches, Institut Curie, Centre Universitaire, Université Paris-Sud, 91405, Orsay, France

    Philippe Maillard

  6. Institut des Sciences Chimiques de Rennes, CNRS UMR 6226, Université de Rennes 1, Campus de Beaulieu, 35042, Rennes Cedex, France

    Olivier Mongin

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  1. Marine Perrier
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  2. Magali Gary-Bobo
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  3. Lenaïc Lartigue
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  7. Philippe Maillard
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  9. Yannick Guari
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  13. Mireille Blanchard-Desce
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Correspondence to Yannick Guari or Jean-Olivier Durand.

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Perrier, M., Gary-Bobo, M., Lartigue, L. et al. Mannose-functionalized porous silica-coated magnetic nanoparticles for two-photon imaging or PDT of cancer cells. J Nanopart Res 15, 1602 (2013). https://doi.org/10.1007/s11051-013-1602-9

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