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Synthesis and surface modification of uniform MFe2O4 (M = Fe, Mn, and Co) nanoparticles with tunable sizes and functionalities

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Abstract

Cubic monodisperse MFe2O4 ferrite nanoparticles (M = Fe, Co, and Mn) with tunable sizes between 7 and 20 nm and a narrow size distribution have been achieved in a one step synthesis by thermal decomposition of Fe(III), Co (II), and Mn(II) oleates. These nanoparticles have been functionalized with dimercaptosuccinic acid (DMSA), 11-mercaptoundecanoic acid (MUA), and bis(carboxymethyl)(2-maleimidylethyl)ammonium 4-toluenesulfonate (MATS) to grant them aqueous stability and the possibility for further functionalization with different biomolecules. Their structural, magnetic, and colloidal properties have also been studied to determine their chemical and physical properties and the degree of stability under physiological conditions that will determine their future use in biomedical applications.

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Abbreviations

NP:

Nanoparticles

MUA:

Dimercaptosuccinic acid: DMSA: 11-mercaptoundecanoic acid

MATS:

bis(carboxymethyl)(2-maleimidylethyl)ammonium 4-toluenesulfonate

DNA:

Deoxyribonucleic acid

RNA:

Ribonucleic acid

RES:

Reticuloendothelial system

rpm:

Revolutions per minute

DMSO:

Dimethyl sulfoxide

KOH:

Potassium hydroxide

HNO3 :

Nitric acid

DMF:

N,N-dimethylformamide

ICP-OES:

Inductively coupled plasma optical emission spectrometry

TEM:

Transmission electron microscopy

TGA:

Thermal gravimetric analysis

FTIR:

Fourier transform infrared

XRD:

X-ray diffraction

DLS:

Dynamic light scattering

PBS:

Phosphate buffered saline

Fe(ole)3 :

Iron (III) oleate

Mn(ole)2 :

Manganese (II) oleate

Co(ole)2 :

Cobalt (II) oleate

H c :

coercivity

M r :

Remanent magnetization

M s :

Saturation magnetic moment

RT:

Room temperature

Fig:

Figure

PZC:

Point of zero charge

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Acknowledgments

This work was supported by the Spanish Ministry of Science and Innovation (MAT2008-01489 to SVV MAT2009-14578-C03-01 for JFM, MAT2011-23641 to MPM, and CSD2007-00010 to MPM) and the Regional Government from Madrid (S009/MAT-1726 to MPM).

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  1. Lourdes I. Cabrera

    Present address: LA.M.M. c/o dipartimento di Chimica, Università degli Studi di Firenze, Via della Lastruccia 3, 50019, Sesto F.no (Fi), Italy

Authors and Affiliations

  1. Instituto de Ciencia de Materiales de Madrid, CSIC, Sor Juana Inés de la Cruz 3, Cantoblanco, Madrid, 28049, Spain

    Lourdes I. Cabrera, Carlos J. Serna & M. Puerto Morales

  2. Faculty of Science Module C-IX, Instituto Madrileño de Estudios Avanzados-Nanociencia, 3rd floor, Cantoblanco, 28049, Madrid, Spain

    Álvaro Somoza

  3. Instituto de Química-Física “ROCASOLANO”, CSIC, C/Serrano 119, 28006, Madrid, Spain

    José F. Marco

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  1. Lourdes I. Cabrera
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Cabrera, L.I., Somoza, Á., Marco, J.F. et al. Synthesis and surface modification of uniform MFe2O4 (M = Fe, Mn, and Co) nanoparticles with tunable sizes and functionalities. J Nanopart Res 14, 873 (2012). https://doi.org/10.1007/s11051-012-0873-x

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