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The role of miRNA in plant–virus interaction: a review

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Abstract

Plant viruses affect crop production both quantitatively and qualitatively. The viral genome consists of either DNA or RNA. However, most plant viruses are positive single-strand RNA viruses. MicroRNAs are involved in gene regulation and affect development as well as host-virus interaction. They are non-coding short with 20–24 nucleotides long capable of regulating gene expression. The miRNA gene is transcribed by RNA polymerase II to form pri-miRNA which will later cleaved by Dicer-like 1 to produce pre-miRNA with the help of HYPONASTIC LEAVES1 and SERRATE which finally methylated and exported via nucleopore with the help of HASTY. The outcome of plant virus interaction depends on the effectiveness of host defense and the ability of a virus counter-defense mechanism. In plants, miRNAs are involved in the repression of gene expression through transcript cleavage. On the other hand, viruses use viral suppressors of RNA silencing (VSRs) which affect RISC assembly and subsequent mRNA degradation. Passenger strands, miRNA*, have a significant biological function in plant defense response as well as plant development.

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  1. Adet Agricultural Research Center, P.O.Box 08, Bahir Dar, Ethiopia

    Anteneh Ademe Mengistu

  2. Addis Ababa University, P.O.Box 1176, Addis Ababa, Ethiopia

    Tesfaye Alemu Tenkegna

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Mengistu, A.A., Tenkegna, T.A. The role of miRNA in plant–virus interaction: a review. Mol Biol Rep 48, 2853–2861 (2021). https://doi.org/10.1007/s11033-021-06290-4

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